Golgi apparatus-targeted aggregation-induced emission luminogens for effective cancer photodynamic therapy

Minglun Liu; Yuncong Chen; Yan Guo; Hao Yuan; Tongxiao Cui; Shankun Yao; Suxing Jin; Huanhuan Fan; Chengjun Wang; Ran Xie; Weijiang He; Zijian Guo

doi:10.1038/s41467-022-29872-7

Nature Communications (Apr 2022)

Golgi apparatus-targeted aggregation-induced emission luminogens for effective cancer photodynamic therapy

Minglun Liu,
Yuncong Chen,
Yan Guo,
Hao Yuan,
Tongxiao Cui,
Shankun Yao,
Suxing Jin,
Huanhuan Fan,
Chengjun Wang,
Ran Xie,
Weijiang He,
Zijian Guo

Affiliations

Minglun Liu: State Key Laboratory of Coordination Chemistry, School of Chemistry and Chemical Engineering, Chemistry and Biomedicine Innovation Center (ChemBIC), Nanjing University
Yuncong Chen: State Key Laboratory of Coordination Chemistry, School of Chemistry and Chemical Engineering, Chemistry and Biomedicine Innovation Center (ChemBIC), Nanjing University
Yan Guo: State Key Laboratory of Coordination Chemistry, School of Chemistry and Chemical Engineering, Chemistry and Biomedicine Innovation Center (ChemBIC), Nanjing University
Hao Yuan: State Key Laboratory of Coordination Chemistry, School of Chemistry and Chemical Engineering, Chemistry and Biomedicine Innovation Center (ChemBIC), Nanjing University
Tongxiao Cui: State Key Laboratory of Coordination Chemistry, School of Chemistry and Chemical Engineering, Chemistry and Biomedicine Innovation Center (ChemBIC), Nanjing University
Shankun Yao: State Key Laboratory of Coordination Chemistry, School of Chemistry and Chemical Engineering, Chemistry and Biomedicine Innovation Center (ChemBIC), Nanjing University
Suxing Jin: State Key Laboratory of Coordination Chemistry, School of Chemistry and Chemical Engineering, Chemistry and Biomedicine Innovation Center (ChemBIC), Nanjing University
Huanhuan Fan: State Key Laboratory of Coordination Chemistry, School of Chemistry and Chemical Engineering, Chemistry and Biomedicine Innovation Center (ChemBIC), Nanjing University
Chengjun Wang: Sinopec Shengli Petroleum Engineering Limited Company
Ran Xie: State Key Laboratory of Coordination Chemistry, School of Chemistry and Chemical Engineering, Chemistry and Biomedicine Innovation Center (ChemBIC), Nanjing University
Weijiang He: State Key Laboratory of Coordination Chemistry, School of Chemistry and Chemical Engineering, Chemistry and Biomedicine Innovation Center (ChemBIC), Nanjing University
Zijian Guo: State Key Laboratory of Coordination Chemistry, School of Chemistry and Chemical Engineering, Chemistry and Biomedicine Innovation Center (ChemBIC), Nanjing University

DOI: https://doi.org/10.1038/s41467-022-29872-7
Journal volume & issue: Vol. 13, no. 1
pp. 1 – 14

Abstract

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Aggregation induced emission luminogen (AIEgen) based photosensitizers (PSs) have been developed for photodynamic cancer therapy. Here the authors report a series of AIEgen-based PSs that selectively target the Golgi apparatus, showing enhanced singlet oxygen generation and photodynamic therapy performance in cancer models.

Published in Nature Communications

ISSN: 2041-1723 (Online)
Publisher: Nature Portfolio
Country of publisher: United Kingdom
LCC subjects: Science
Website: https://www.nature.com/ncomms/

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