Nature Communications (Sep 2019)

Epigenome editing strategies for the functional annotation of CTCF insulators

  • Daniel R. Tarjan,
  • William A. Flavahan,
  • Bradley E. Bernstein

DOI
https://doi.org/10.1038/s41467-019-12166-w
Journal volume & issue
Vol. 10, no. 1
pp. 1 – 8

Abstract

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The role of CTCF-bound insulator elements in enhancer-gene interactions and transcriptional regulation remains poorly understood. Here, the authors investigate multiple epigenome editing strategies for perturbing individual CTCF-bound insulators, and evaluate their effects on genome topology and transcription.