Nature Communications (Feb 2020)
Bacillus cereus non-haemolytic enterotoxin activates the NLRP3 inflammasome
- Daniel Fox,
- Anukriti Mathur,
- Yansong Xue,
- Yunqi Liu,
- Wei Hong Tan,
- Shouya Feng,
- Abhimanu Pandey,
- Chinh Ngo,
- Jenni A. Hayward,
- Ines I. Atmosukarto,
- Jason D. Price,
- Matthew D. Johnson,
- Nadja Jessberger,
- Avril A. B. Robertson,
- Gaetan Burgio,
- David C. Tscharke,
- Edward M. Fox,
- Denisse L. Leyton,
- Nadeem O. Kaakoush,
- Erwin Märtlbauer,
- Stephen H. Leppla,
- Si Ming Man
Affiliations
- Daniel Fox
- Department of Immunology and Infectious Disease, The John Curtin School of Medical Research, The Australian National University
- Anukriti Mathur
- Department of Immunology and Infectious Disease, The John Curtin School of Medical Research, The Australian National University
- Yansong Xue
- Department of Immunology and Infectious Disease, The John Curtin School of Medical Research, The Australian National University
- Yunqi Liu
- Department of Immunology and Infectious Disease, The John Curtin School of Medical Research, The Australian National University
- Wei Hong Tan
- Department of Immunology and Infectious Disease, The John Curtin School of Medical Research, The Australian National University
- Shouya Feng
- Department of Immunology and Infectious Disease, The John Curtin School of Medical Research, The Australian National University
- Abhimanu Pandey
- Department of Immunology and Infectious Disease, The John Curtin School of Medical Research, The Australian National University
- Chinh Ngo
- Department of Immunology and Infectious Disease, The John Curtin School of Medical Research, The Australian National University
- Jenni A. Hayward
- Department of Immunology and Infectious Disease, The John Curtin School of Medical Research, The Australian National University
- Ines I. Atmosukarto
- Lipotek Pty Ltd. The John Curtin School of Medical Research, The Australian National University
- Jason D. Price
- Lipotek Pty Ltd. The John Curtin School of Medical Research, The Australian National University
- Matthew D. Johnson
- Research School of Biology, The Australian National University
- Nadja Jessberger
- Department of Veterinary Sciences, Faculty of Veterinary Medicine, Ludwig-Maximilians-Universität München
- Avril A. B. Robertson
- School of Chemistry and Molecular Biosciences, The University of Queensland
- Gaetan Burgio
- Department of Immunology and Infectious Disease, The John Curtin School of Medical Research, The Australian National University
- David C. Tscharke
- Department of Immunology and Infectious Disease, The John Curtin School of Medical Research, The Australian National University
- Edward M. Fox
- Department of Applied Sciences, Northumbria University
- Denisse L. Leyton
- Research School of Biology, The Australian National University
- Nadeem O. Kaakoush
- School of Medical Sciences, UNSW Sydney
- Erwin Märtlbauer
- Department of Veterinary Sciences, Faculty of Veterinary Medicine, Ludwig-Maximilians-Universität München
- Stephen H. Leppla
- Microbial Pathogenesis Section, Laboratory of Parasitic Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health
- Si Ming Man
- Department of Immunology and Infectious Disease, The John Curtin School of Medical Research, The Australian National University
- DOI
- https://doi.org/10.1038/s41467-020-14534-3
- Journal volume & issue
-
Vol. 11,
no. 1
pp. 1 – 16
Abstract
The Bacillus haemolytic enterotoxin haemolysin BL has been shown to activate the NLRP3 inflammasome. Here the authors show that a non-haemolytic enterotoxin (NHE) from B. cereus can also activate the NLRP3 inflammasome with a similar mechanism of lytic pore formation.
