Nature Communications (Aug 2022)
Rational design of a sensitivity-enhanced tracer for discovering efficient APC–Asef inhibitors
- Jie Zhong,
- Yuegui Guo,
- Shaoyong Lu,
- Kun Song,
- Ying Wang,
- Li Feng,
- Zhen Zheng,
- Qiufen Zhang,
- Jiacheng Wei,
- Peng Sang,
- Yan Shi,
- Jianfeng Cai,
- Guoqiang Chen,
- Chen-Ying Liu,
- Xiuyan Yang,
- Jian Zhang
Affiliations
- Jie Zhong
- State Key Laboratory of Medical Genomics, National Research Center for Translational Medicine at Shanghai, Ruijin Hospital, Shanghai Jiao Tong University School of Medicine
- Yuegui Guo
- Department of Colorectal and Anal Surgery, Xinhua Hospital, Shanghai Jiao Tong University School of Medicine
- Shaoyong Lu
- Department of Pathophysiology, Key Laboratory of Cell Differentiation and Apoptosis of Chinese Ministry of Education, Shanghai Jiao Tong University School of Medicine
- Kun Song
- Department of Pathophysiology, Key Laboratory of Cell Differentiation and Apoptosis of Chinese Ministry of Education, Shanghai Jiao Tong University School of Medicine
- Ying Wang
- Department of Pathophysiology, Key Laboratory of Cell Differentiation and Apoptosis of Chinese Ministry of Education, Shanghai Jiao Tong University School of Medicine
- Li Feng
- Medicinal Chemistry and Bioinformatics Center, Shanghai Jiao Tong University School of Medicine
- Zhen Zheng
- Medicinal Chemistry and Bioinformatics Center, Shanghai Jiao Tong University School of Medicine
- Qiufen Zhang
- Medicinal Chemistry and Bioinformatics Center, Shanghai Jiao Tong University School of Medicine
- Jiacheng Wei
- Department of Pathophysiology, Key Laboratory of Cell Differentiation and Apoptosis of Chinese Ministry of Education, Shanghai Jiao Tong University School of Medicine
- Peng Sang
- Department of Chemistry, University of South Florida
- Yan Shi
- Department of Chemistry, University of South Florida
- Jianfeng Cai
- Department of Chemistry, University of South Florida
- Guoqiang Chen
- Research Unit of Stress and Cancer, Chinese Academy of Medical Sciences
- Chen-Ying Liu
- Department of Colorectal and Anal Surgery, Xinhua Hospital, Shanghai Jiao Tong University School of Medicine
- Xiuyan Yang
- Department of Pathophysiology, Key Laboratory of Cell Differentiation and Apoptosis of Chinese Ministry of Education, Shanghai Jiao Tong University School of Medicine
- Jian Zhang
- State Key Laboratory of Medical Genomics, National Research Center for Translational Medicine at Shanghai, Ruijin Hospital, Shanghai Jiao Tong University School of Medicine
- DOI
- https://doi.org/10.1038/s41467-022-32612-6
- Journal volume & issue
-
Vol. 13,
no. 1
pp. 1 – 14
Abstract
The adenomatous polyposis coli (APC)–Asef protein interaction is essential for colorectal cancer metastasis. Here, the authors present the rational design of a sensitivity-enhanced tracer for fluorescence polarization assays, enabling them to discover more efficient APC–Asef interaction inhibitors.
