Journal of Education, Health and Sport (Jul 2017)

Expression of vimentin, E-cadherin and TGF-β as markers of epithelial-mesenchymal transformation and criteria for the prognosis of the diseaseby epithelium in benign pathology and prostate gland cancer

  • P. V. Tkachenko,
  • I. I. Yakovtcova,
  • O. V. Dolgaya,
  • I. V. Ivakhno

DOI
https://doi.org/10.5281/zenodo.843519
Journal volume & issue
Vol. 7, no. 7
pp. 764 – 775

Abstract

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Epithelial-mesenchymal transformation in prostate gland cancer is a criterion of aggressive biological behavior of the tumor, but the clinical material is not sufficiently studied. The objective of the research was to study epithelial-mesenchymal transformation and its prognostic significance in benign pathology and prostate gland cancer. The absence of vimentin expression and the evident reaction of E-cadherin in the epithelium in benign pathology of the prostate glandwere revealed. The change in the expression of these markers in prostate gland canceroccur at the expense of low-differentiated forms and is characteristic of the high-risk group (p <0.05 and p <0.01, respectively). An inverse dependence between the reaction of vimentin and E-cadherin (p <0.05) and their correlation withTGFβ (p <0.05) was detected. Conclusion: community of the molecular-biological manifestations of the epithelial-mesenchymal transformation in prostate gland cancer and involvement of TGFβ into its process has been proved. Epithelial-mesenchymal transformation maybe a prognostic criterionof the disease.

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