Antiplasmodial and Leishmanicidal Activities of 2-Cyano-3-(4-phenylpiperazine-1-carboxamido) Quinoxaline 1,4-Dioxide Derivatives

Abstract

Malaria and leishmaniasis are two of the World’s most important tropical parasitic diseases. Thirteen new 2-cyano-3-(4-phenylpiperazine-1-carboxamido) quinoxaline 1,4-dioxide derivatives (CPCQs) were synthesized and evaluated for their <em>in vitro</em> antimalarial and antileishmanial activity against erythrocytic forms of <em>Plasmodium falciparum</em> and axenic forms of <em>Leishmania infantum</em>. Their toxicity against VERO cells (normal monkey kidney cells) was also assessed. None of the tested compounds was efficient against <em>Plasmodium</em>, but two of them showed good activity against <em>Leishmania</em>. Toxicity on VERO was correlated with leishmanicidal properties.

Keywords

• quinoxaline
• piperazine
• &lt;em&gt;Plasmodium&lt;/em&gt;
• &lt;em&gt;Leishmania&lt;/em&gt;
• VERO