An oncolytic virus expressing a full-length antibody enhances antitumor innate immune response to glioblastoma

Bo Xu; Lei Tian; Jing Chen; Jing Wang; Rui Ma; Wenjuan Dong; Aimin Li; Jianying Zhang; E. Antonio Chiocca; Balveen Kaur; Mingye Feng; Michael A. Caligiuri; Jianhua Yu

doi:10.1038/s41467-021-26003-6

Nature Communications (Oct 2021)

An oncolytic virus expressing a full-length antibody enhances antitumor innate immune response to glioblastoma

Bo Xu,
Lei Tian,
Jing Chen,
Jing Wang,
Rui Ma,
Wenjuan Dong,
Aimin Li,
Jianying Zhang,
E. Antonio Chiocca,
Balveen Kaur,
Mingye Feng,
Michael A. Caligiuri,
Jianhua Yu

Affiliations

Bo Xu: Department of Hematology and Hematopoietic Cell Transplantation, City of Hope National Medical Center
Lei Tian: Department of Hematology and Hematopoietic Cell Transplantation, City of Hope National Medical Center
Jing Chen: Department of Immuno-Oncology, Beckman Research Institute, City of Hope Comprehensive Cancer Centre
Jing Wang: Department of Hematology and Hematopoietic Cell Transplantation, City of Hope National Medical Center
Rui Ma: Department of Hematology and Hematopoietic Cell Transplantation, City of Hope National Medical Center
Wenjuan Dong: Department of Hematology and Hematopoietic Cell Transplantation, City of Hope National Medical Center
Aimin Li: Pathology Core of Shared Resources Core, Beckman Research Institute, City of Hope National Medical Center
Jianying Zhang: Department of Computational and Quantitative Medicine, City of Hope National Medical Center
E. Antonio Chiocca: Department of Neurosurgery, Brigham and Women’s Hospital and Harvey Cushing Neuro-oncology Laboratories, Harvard Medical School
Balveen Kaur: The Vivian L. Smith Department of Neurosurgery, Mc Govern Medical School, University of Texas, University of Texas Health Science Center at Houston
Mingye Feng: Department of Immuno-Oncology, Beckman Research Institute, City of Hope Comprehensive Cancer Centre
Michael A. Caligiuri: Department of Hematology and Hematopoietic Cell Transplantation, City of Hope National Medical Center
Jianhua Yu: Department of Hematology and Hematopoietic Cell Transplantation, City of Hope National Medical Center

DOI: https://doi.org/10.1038/s41467-021-26003-6
Journal volume & issue: Vol. 12, no. 1
pp. 1 – 17

Abstract

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Oncolytic herpes simplex virus-1 lyses cancer cells while increases their immunogenicity. Blocking the CD47 “don’t eat me” signal on cancer cells promotes their phagocytosis by macrophages. Authors here show that oncolytic viruses expressing anti-CD47 antibodies improve glioblastoma survival in mouse models.

Published in Nature Communications

ISSN: 2041-1723 (Online)
Publisher: Nature Portfolio
Country of publisher: United Kingdom
LCC subjects: Science
Website: https://www.nature.com/ncomms/

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