Application and research progress of bone marrow mesenchymal stem cells in corneal injury repair

Abstract

Bone marrow mesenchymal stem cells(BMSCs)are a class of cells that can differentiate into different kind of corneal cells both in vitro and in vivo, which include corneal epithelial cells, limbal epithelial cells and corneal stromal cells. BMSCs could differentiate into corneal epithelial cells after transplantation, which can not only repair the damaged corneal, but also relieve inflammatory injury caused by the inflammatory cell infiltration. The other function of BMSC transplantation is to reduce the rejection after corneal transplantation by inhibiting cell damage and apoptosis. BMSC can also express a variety of factors on the carrier, these factors paly the important role in promoting the proliferation of limbal stem cells. These findings above provide a new direction for the fundamental study of ophthalmology, and put forward new clinical treatment ideas for corneal disease, both of them have broad protect for development. In this paper, the research status and progress of BMSC in the repair of corneal injury are reviewed.

Keywords

• bone marrow mesenchymal stem cells
• corneal injury repair
• research
• application
• application