The transcription factor Foxp1 preserves integrity of an active Foxp3 locus in extrathymic Treg cells

Sayantani Ghosh; Sinchita Roy-Chowdhuri; Keunsoo Kang; Sin-Hyeog Im; Dipayan Rudra

doi:10.1038/s41467-018-07018-y

Nature Communications (Oct 2018)

The transcription factor Foxp1 preserves integrity of an active Foxp3 locus in extrathymic Treg cells

Sayantani Ghosh,
Sinchita Roy-Chowdhuri,
Keunsoo Kang,
Sin-Hyeog Im,
Dipayan Rudra

Affiliations

Sayantani Ghosh: Academy of Immunology and Microbiology, Institute for Basic Science (IBS)
Sinchita Roy-Chowdhuri: Department of Pathology, The University of Texas MD Anderson Cancer Center
Keunsoo Kang: Department of Microbiology, College of Natural Sciences, Dankook University
Sin-Hyeog Im: Academy of Immunology and Microbiology, Institute for Basic Science (IBS)
Dipayan Rudra: Academy of Immunology and Microbiology, Institute for Basic Science (IBS)

DOI: https://doi.org/10.1038/s41467-018-07018-y
Journal volume & issue: Vol. 9, no. 1
pp. 1 – 14

Abstract

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Regulatory T (Treg) cells suppress immune cell activation to maintain immune homeostasis, and have their lineage enforced by the master transcription factor Foxp3. Here the authors show that Foxp3 expression is promoted and maintained by a related family member, Foxp1, specifically in peripherally induced Treg but not in Treg cells of thymic origin.

Published in Nature Communications

ISSN: 2041-1723 (Online)
Publisher: Nature Portfolio
Country of publisher: United Kingdom
LCC subjects: Science
Website: https://www.nature.com/ncomms/

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