Enantioselective three-component aminomethylation of α-diazo ketones with alcohols and 1,3,5-triazines

Jiuwei Che; Li Niu; Shikun Jia; Dong Xing; Wenhao Hu

doi:10.1038/s41467-020-15345-2

Nature Communications (Mar 2020)

Enantioselective three-component aminomethylation of α-diazo ketones with alcohols and 1,3,5-triazines

Jiuwei Che,
Li Niu,
Shikun Jia,
Dong Xing,
Wenhao Hu

Affiliations

Jiuwei Che: Shanghai Engineering Research Center of Molecular Therapeutics and New Drug Development, School of Chemistry and Molecular Engineering, East China Normal University
Li Niu: Shanghai Engineering Research Center of Molecular Therapeutics and New Drug Development, School of Chemistry and Molecular Engineering, East China Normal University
Shikun Jia: Guangdong Key Laboratory of Chiral Molecule and Drug Discovery, School of Pharmaceutical Sciences, Sun Yat-sen University
Dong Xing: Shanghai Engineering Research Center of Molecular Therapeutics and New Drug Development, School of Chemistry and Molecular Engineering, East China Normal University
Wenhao Hu: Guangdong Key Laboratory of Chiral Molecule and Drug Discovery, School of Pharmaceutical Sciences, Sun Yat-sen University

DOI: https://doi.org/10.1038/s41467-020-15345-2
Journal volume & issue: Vol. 11, no. 1
pp. 1 – 9

Abstract

Read online

Strategies for enantioselective α-aminomethylation of carbonyl compounds rely on the chiral activation of stable ketones substrate. Here, the authors report a rhodium/chiral phosphoric acid cooperative catalysis for the three-component reaction of α-diazo ketones with alcohols and 1,3,5-triazines via imine chiral activation.

Published in Nature Communications

ISSN: 2041-1723 (Online)
Publisher: Nature Portfolio
Country of publisher: United Kingdom
LCC subjects: Science
Website: https://www.nature.com/ncomms/

About the journal