Epigenetic landscape of pancreatic neuroendocrine tumours reveals distinct cells of origin and means of tumour progression

Annunziata Di Domenico; Christodoulos P. Pipinikas; Renaud S. Maire; Konstantin Bräutigam; Cedric Simillion; Matthias S. Dettmer; Erik Vassella; Chrissie Thirlwell; Aurel Perren; Ilaria Marinoni

doi:10.1038/s42003-020-01479-y

Communications Biology (Dec 2020)

Epigenetic landscape of pancreatic neuroendocrine tumours reveals distinct cells of origin and means of tumour progression

Annunziata Di Domenico,
Christodoulos P. Pipinikas,
Renaud S. Maire,
Konstantin Bräutigam,
Cedric Simillion,
Matthias S. Dettmer,
Erik Vassella,
Chrissie Thirlwell,
Aurel Perren,
Ilaria Marinoni

Affiliations

Annunziata Di Domenico: Institute of Pathology, University of Bern
Christodoulos P. Pipinikas: UCL Cancer Institute
Renaud S. Maire: Institute of Pathology, University of Bern
Konstantin Bräutigam: Institute of Pathology, University of Bern
Cedric Simillion: Bioinformatics and Computational Biology, University of Bern
Matthias S. Dettmer: Institute of Pathology, University of Bern
Erik Vassella: Institute of Pathology, University of Bern
Chrissie Thirlwell: UCL Cancer Institute
Aurel Perren: Institute of Pathology, University of Bern
Ilaria Marinoni: Institute of Pathology, University of Bern

DOI: https://doi.org/10.1038/s42003-020-01479-y
Journal volume & issue: Vol. 3, no. 1
pp. 1 – 11

Abstract

Read online

Di Domenico et al., provide a comprehensive assessment of DNA methylation in a large cohort of pancreatic neuroendocrine tumors. This work provides new insights into the epigenetic heterogeneity of the disease and cellular basis.

Published in Communications Biology

ISSN: 2399-3642 (Online)
Publisher: Nature Portfolio
Country of publisher: United Kingdom
LCC subjects: Science: Biology (General)
Website: https://www.nature.com/commsbio/

About the journal