BMC Pulmonary Medicine (Oct 2021)
Management of patients with pulmonary mycobacteriosis in France: a multicenter retrospective cohort study
- Pascale Bemer,
- Olivia Peuchant,
- Hélène Guet-Revillet,
- Julien Bador,
- Charlotte Balavoine,
- Damien Basille,
- Guillaume Beltramo,
- François-Xavier Blanc,
- Elodie Blanchard,
- Sarah Boulanger,
- Anne Bourgoin,
- David Boutoille,
- Emmanuelle Cambau,
- Frédérique Canis,
- Didier Caparros,
- Anne Carricajo,
- Christian Carrière,
- Gérard Couetdic,
- Francis Couturaud,
- Jean-Charles Dalphin,
- Tristan Degot,
- Marion Desquiens,
- Gilles Devouassoux,
- Jean-Marie Duez,
- Oana Dumitrescu,
- Magali Dupuy-Grasset,
- Alice Gaudart,
- Marjolaine Georges,
- Cendrine Godet,
- Sylvain Godreuil,
- Aurélie Guillouzouic,
- Farida Hamdad-Daoudi,
- Geneviève Héry-Arnaud,
- Christelle Koebel,
- Aurore Lagrange,
- Philippe Lanotte,
- Sylvain Marchand-Adam,
- Faïza Mougari,
- Marlène Murris,
- Isabelle Patry,
- Michèle Pérouse de Montclos,
- Laurent Raskine,
- Karine Risso,
- Christine Segonds,
- Dominique Sicard,
- Dominique Terru,
- Anne Vachée,
- Jean-Michel Vergnon,
- Christian Martin,
- Frédéric Schramm,
- Claire Andrejak
Affiliations
- Pascale Bemer
- Department of Bacteriology, CHU Nantes
- Olivia Peuchant
- Department of Bacteriology, CHU Bordeaux
- Hélène Guet-Revillet
- Department of Bacteriology, CHU Toulouse
- Julien Bador
- Department of Bacteriology, CHU Dijon
- Charlotte Balavoine
- Department of Respiratory Diseases, CHU Tours
- Damien Basille
- Department of Respiratory Diseases, Amiens University Hospital, CHU Amiens
- Guillaume Beltramo
- Department of Respiratory Diseases, CHU Dijon
- François-Xavier Blanc
- Department of Respiratory Diseases, CHU Nantes
- Elodie Blanchard
- Department of Respiratory Diseases, CHU Bordeaux
- Sarah Boulanger
- Department of Respiratory Diseases, CH Roubaix
- Anne Bourgoin
- Department of Bacteriology, CHU Poitiers
- David Boutoille
- Department of Infectious Disease, CHU Nantes
- Emmanuelle Cambau
- Department of Bacteriology, AP-HP
- Frédérique Canis
- Department of Bacteriology, CH Valenciennes
- Didier Caparros
- Department of Respiratory Diseases, CH Valenciennes
- Anne Carricajo
- Department of Bacteriology, CHU Saint Etienne
- Christian Carrière
- Department of Bacteriology, CHU Montpellier
- Gérard Couetdic
- Department of Bacteriology, CHU Besançon
- Francis Couturaud
- Department of Respiratory Diseases, CHU Brest
- Jean-Charles Dalphin
- Department of Respiratory Diseases, CHU Besançon
- Tristan Degot
- Department of Respiratory Diseases, CHRU Strasbourg
- Marion Desquiens
- Department of Respiratory Diseases, Amiens University Hospital, CHU Amiens
- Gilles Devouassoux
- Department of Respiratory Diseases, Hospices Civils Lyon
- Jean-Marie Duez
- Department of Bacteriology, CHU Dijon
- Oana Dumitrescu
- Department of Bacteriology, Hospices Civils Lyon
- Magali Dupuy-Grasset
- Department of Respiratory Diseases, CHU Limoges
- Alice Gaudart
- Department of Bacteriology, CHU Nice
- Marjolaine Georges
- Department of Respiratory Diseases, CHU Dijon
- Cendrine Godet
- Department of Respiratory Diseases, CHU Poitiers
- Sylvain Godreuil
- Department of Bacteriology, CHU Montpellier
- Aurélie Guillouzouic
- Department of Bacteriology, CHU Nantes
- Farida Hamdad-Daoudi
- Department of Bacteriology, CHU Amiens
- Geneviève Héry-Arnaud
- Department of Bacteriology, CHU Brest
- Christelle Koebel
- Department of Bacteriology, CHRU Strasbourg
- Aurore Lagrange
- Department of Respiratory Diseases, Amiens University Hospital, CHU Amiens
- Philippe Lanotte
- Department of Bacteriology, CHU Tours
- Sylvain Marchand-Adam
- Department of Respiratory Diseases, CHU Tours
- Faïza Mougari
- Department of Bacteriology, AP-HP
- Marlène Murris
- Department of Respiratory Diseases, CHU Toulouse
- Isabelle Patry
- Department of Bacteriology, CHU Besançon
- Michèle Pérouse de Montclos
- Department of Bacteriology, Hospices Civils Lyon
- Laurent Raskine
- Department of Bacteriology, AP-HP
- Karine Risso
- Department of Respiratory Diseases, CHU Nice
- Christine Segonds
- Department of Bacteriology, CHU Toulouse
- Dominique Sicard
- Department of Bacteriology, CHU Nice
- Dominique Terru
- Department of Bacteriology, CHU Montpellier
- Anne Vachée
- Department of Bacteriology, CH Roubaix
- Jean-Michel Vergnon
- Department of Respiratory Diseases, CHU Saint Etienne
- Christian Martin
- Department of Bacteriology, CHU Limoges
- Frédéric Schramm
- Department of Bacteriology, CHRU Strasbourg
- Claire Andrejak
- Department of Respiratory Diseases, Amiens University Hospital, CHU Amiens
- DOI
- https://doi.org/10.1186/s12890-021-01701-5
- Journal volume & issue
-
Vol. 21,
no. 1
pp. 1 – 9
Abstract
Abstract Background Recent studies report very low adherence of practitioners to ATS/IDSA recommendations for the treatment of nontuberculous mycobacteria pulmonary disease (NTM-PD), as well as a great variability of practices. Type of management could impact prognosis. Methods To evaluate management and prognosis of patients with NTM-PD cases with respect to ATS recommendations, we conducted a multicenter retrospective cohort study (18 sentinel sites distributed throughout France), over a period of six years. We collected clinical, radiological, microbiological characteristics, management and outcome of the patients (especially death or not). Results 477 patients with NTM-PD were included. Respiratory comorbidities were found in 68% of cases, tuberculosis sequelae in 31.4% of patients, and immunosuppression in 16.8% of cases. The three most common NTM species were Mycobacterium avium complex (60%), M. xenopi (20%) and M. kansasii (5.7%). Smear-positive was found in one third of NTM-PD. Nodulobronchiectatic forms were observed in 54.3% of cases, and cavitary forms in 19.1% of patients. Sixty-three percent of patients were treated, 72.4% of patients with smear-positive samples, and 57.5% of patients with smear-negative samples. Treatment was in adequacy with ATS guidelines in 73.5%. The 2-year mortality was 14.4%. In the Cox regression, treatment (HR = 0.51), age (HR = 1.02), and M. abscessus (3.19) appeared as the 3 significant independent prognostic factors. Conclusion These findings highlight the adequacy between French practices and the ATS/IDSA guidelines. Treatment was associated with a better survival.
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