Frontiers in Oncology (Aug 2017)
Relationships between Regional Radiation Doses and Cognitive Decline in Children Treated with Cranio-Spinal Irradiation for Posterior Fossa Tumors
- Elodie Doger de Speville,
- Elodie Doger de Speville,
- Elodie Doger de Speville,
- Charlotte Robert,
- Charlotte Robert,
- Charlotte Robert,
- Charlotte Robert,
- Martin Perez-Guevara,
- Antoine Grigis,
- Stephanie Bolle,
- Clemence Pinaud,
- Clemence Pinaud,
- Christelle Dufour,
- Anne Beaudré,
- Anne Beaudré,
- Virginie Kieffer,
- Virginie Kieffer,
- Audrey Longaud,
- Audrey Longaud,
- Jacques Grill,
- Jacques Grill,
- Dominique Valteau-Couanet,
- Dominique Valteau-Couanet,
- Eric Deutsch,
- Eric Deutsch,
- Eric Deutsch,
- Eric Deutsch,
- Dimitri Lefkopoulos,
- Dimitri Lefkopoulos,
- Catherine Chiron,
- Catherine Chiron,
- Lucie Hertz-Pannier,
- Lucie Hertz-Pannier,
- Marion Noulhiane,
- Marion Noulhiane
Affiliations
- Elodie Doger de Speville
- INSERM U1129, CEA, Paris Descartes University, Paris, France
- Elodie Doger de Speville
- UNIACT, Institut Joliot, DRF, Neurospin, CEA, Paris Saclay University, Gif-sur-Yvette, France
- Elodie Doger de Speville
- Department of Pediatric and Adolescent Oncology, Gustave Roussy, Villejuif, France
- Charlotte Robert
- Radiation Oncology Department, Gustave Roussy Cancer Campus, Villejuif, France
- Charlotte Robert
- INSERM, U1030, Villejuif, France
- Charlotte Robert
- Paris Sud University, Paris-Saclay University, Villejuif, France
- Charlotte Robert
- Gustave Roussy, Paris-Saclay University, Department of Medical Physics, Villejuif, France
- Martin Perez-Guevara
- INSERM U992 Unicog CEA, Neurospin, Paris Descartes University, Paris, France
- Antoine Grigis
- Institut Joliot, Neurospin, CEA, Paris-Saclay University, Gif-sur-Yvette, France
- Stephanie Bolle
- Radiation Oncology Department, Gustave Roussy Cancer Campus, Villejuif, France
- Clemence Pinaud
- INSERM U1129, CEA, Paris Descartes University, Paris, France
- Clemence Pinaud
- UNIACT, Institut Joliot, DRF, Neurospin, CEA, Paris Saclay University, Gif-sur-Yvette, France
- Christelle Dufour
- Department of Pediatric and Adolescent Oncology, Gustave Roussy, Villejuif, France
- Anne Beaudré
- Radiation Oncology Department, Gustave Roussy Cancer Campus, Villejuif, France
- Anne Beaudré
- Gustave Roussy, Paris-Saclay University, Department of Medical Physics, Villejuif, France
- Virginie Kieffer
- Department of Pediatric and Adolescent Oncology, Gustave Roussy, Villejuif, France
- Virginie Kieffer
- 0CSI Department for Children with Acquired Brain Injury, Hopitaux de Saint Maurice, Saint-Maurice, France
- Audrey Longaud
- Department of Pediatric and Adolescent Oncology, Gustave Roussy, Villejuif, France
- Audrey Longaud
- 1Paris Sud University, Orsay, France
- Jacques Grill
- Department of Pediatric and Adolescent Oncology, Gustave Roussy, Villejuif, France
- Jacques Grill
- 1Paris Sud University, Orsay, France
- Dominique Valteau-Couanet
- Department of Pediatric and Adolescent Oncology, Gustave Roussy, Villejuif, France
- Dominique Valteau-Couanet
- 1Paris Sud University, Orsay, France
- Eric Deutsch
- Radiation Oncology Department, Gustave Roussy Cancer Campus, Villejuif, France
- Eric Deutsch
- INSERM, U1030, Villejuif, France
- Eric Deutsch
- Paris Sud University, Paris-Saclay University, Villejuif, France
- Eric Deutsch
- Gustave Roussy, Paris-Saclay University, Department of Medical Physics, Villejuif, France
- Dimitri Lefkopoulos
- Radiation Oncology Department, Gustave Roussy Cancer Campus, Villejuif, France
- Dimitri Lefkopoulos
- Gustave Roussy, Paris-Saclay University, Department of Medical Physics, Villejuif, France
- Catherine Chiron
- INSERM U1129, CEA, Paris Descartes University, Paris, France
- Catherine Chiron
- UNIACT, Institut Joliot, DRF, Neurospin, CEA, Paris Saclay University, Gif-sur-Yvette, France
- Lucie Hertz-Pannier
- INSERM U1129, CEA, Paris Descartes University, Paris, France
- Lucie Hertz-Pannier
- UNIACT, Institut Joliot, DRF, Neurospin, CEA, Paris Saclay University, Gif-sur-Yvette, France
- Marion Noulhiane
- INSERM U1129, CEA, Paris Descartes University, Paris, France
- Marion Noulhiane
- UNIACT, Institut Joliot, DRF, Neurospin, CEA, Paris Saclay University, Gif-sur-Yvette, France
- DOI
- https://doi.org/10.3389/fonc.2017.00166
- Journal volume & issue
-
Vol. 7
Abstract
Pediatric posterior fossa tumor (PFT) survivors who have been treated with cranial radiation therapy often suffer from cognitive impairments that might relate to IQ decline. Radiotherapy (RT) distinctly affects brain regions involved in different cognitive functions. However, the relative contribution of regional irradiation to the different cognitive impairments still remains unclear. We investigated the relationships between the changes in different cognitive scores and radiation dose distribution in 30 children treated for a PFT. Our exploratory analysis was based on a principal component analysis (PCA) and an ordinary least square regression approach. The use of a PCA was an innovative way to cluster correlated irradiated regions due to similar radiation therapy protocols across patients. Our results suggest an association between working memory decline and a high dose (equivalent uniform dose, EUD) delivered to the orbitofrontal regions, whereas the decline of processing speed seemed more related to EUD in the temporal lobes and posterior fossa. To identify regional effects of RT on cognitive functions may help to propose a rehabilitation program adapted to the risk of cognitive impairment.
Keywords
