Nature Communications (Mar 2017)
Chd7 is indispensable for mammalian brain development through activation of a neuronal differentiation programme
- Weijun Feng,
- Daisuke Kawauchi,
- Huiqin Körkel-Qu,
- Huan Deng,
- Elisabeth Serger,
- Laura Sieber,
- Jenna Ariel Lieberman,
- Silvia Jimeno-González,
- Sander Lambo,
- Bola S. Hanna,
- Yassin Harim,
- Malin Jansen,
- Anna Neuerburg,
- Olga Friesen,
- Marc Zuckermann,
- Vijayanad Rajendran,
- Jan Gronych,
- Olivier Ayrault,
- Andrey Korshunov,
- David T. W. Jones,
- Marcel Kool,
- Paul A. Northcott,
- Peter Lichter,
- Felipe Cortés-Ledesma,
- Stefan M. Pfister,
- Hai-Kun Liu
Affiliations
- Weijun Feng
- Division of Molecular Neurogenetics, German Cancer Research Center (DKFZ), DKFZ–ZMBH Alliance
- Daisuke Kawauchi
- Division of Pediatric Neuro-oncology, German Cancer Research Center (DKFZ)
- Huiqin Körkel-Qu
- Division of Molecular Neurogenetics, German Cancer Research Center (DKFZ), DKFZ–ZMBH Alliance
- Huan Deng
- Division of Molecular Neurogenetics, German Cancer Research Center (DKFZ), DKFZ–ZMBH Alliance
- Elisabeth Serger
- Division of Molecular Neurogenetics, German Cancer Research Center (DKFZ), DKFZ–ZMBH Alliance
- Laura Sieber
- Division of Pediatric Neuro-oncology, German Cancer Research Center (DKFZ)
- Jenna Ariel Lieberman
- Centro Andaluz de Biología Molecular y Medicina Regenerativa (CABIMER), CSIC-Universidad de Sevilla-Universidad Pablo de Olavide
- Silvia Jimeno-González
- Centro Andaluz de Biología Molecular y Medicina Regenerativa (CABIMER), CSIC-Universidad de Sevilla-Universidad Pablo de Olavide
- Sander Lambo
- Division of Pediatric Neuro-oncology, German Cancer Research Center (DKFZ)
- Bola S. Hanna
- Molecular Genetics, German Cancer Research Center (DKFZ)
- Yassin Harim
- Division of Molecular Neurogenetics, German Cancer Research Center (DKFZ), DKFZ–ZMBH Alliance
- Malin Jansen
- Division of Molecular Neurogenetics, German Cancer Research Center (DKFZ), DKFZ–ZMBH Alliance
- Anna Neuerburg
- Division of Molecular Neurogenetics, German Cancer Research Center (DKFZ), DKFZ–ZMBH Alliance
- Olga Friesen
- Division of Molecular Neurogenetics, German Cancer Research Center (DKFZ), DKFZ–ZMBH Alliance
- Marc Zuckermann
- Molecular Genetics, German Cancer Research Center (DKFZ)
- Vijayanad Rajendran
- Division of Pediatric Neuro-oncology, German Cancer Research Center (DKFZ)
- Jan Gronych
- Molecular Genetics, German Cancer Research Center (DKFZ)
- Olivier Ayrault
- Institut Curie, CNRS UMR 3347, INSERM U1021, Centre Universitaire
- Andrey Korshunov
- Department of Neuropathology, Clinical Cooperation Unit Neuropathology, German Cancer Research Centre (DKFZ), University of Heidelberg
- David T. W. Jones
- Division of Pediatric Neuro-oncology, German Cancer Research Center (DKFZ)
- Marcel Kool
- Division of Pediatric Neuro-oncology, German Cancer Research Center (DKFZ)
- Paul A. Northcott
- Department of Developmental Neurobiology, St. Jude Children’s Research Hospital
- Peter Lichter
- Molecular Genetics, German Cancer Research Center (DKFZ)
- Felipe Cortés-Ledesma
- Centro Andaluz de Biología Molecular y Medicina Regenerativa (CABIMER), CSIC-Universidad de Sevilla-Universidad Pablo de Olavide
- Stefan M. Pfister
- Division of Pediatric Neuro-oncology, German Cancer Research Center (DKFZ)
- Hai-Kun Liu
- Division of Molecular Neurogenetics, German Cancer Research Center (DKFZ), DKFZ–ZMBH Alliance
- DOI
- https://doi.org/10.1038/ncomms14758
- Journal volume & issue
-
Vol. 8,
no. 1
pp. 1 – 14
Abstract
Mutations in the chromatin modifier Chd7 have been associated with CHARGE syndrome and other developmental disorders. Here the authors show that Chd7 is required for the activation of genes essential for cerebellar granule cell differentiation, and that disrupting Chd7 leads to cerebellar hypoplasia in mice.
