Long-term dynamics of aberrant neuronal activity in awake Alzheimer’s disease transgenic mice

Abstract

To advance our understanding of aberrant neuronal activity in Alzheimer’s disease (AD) Korzhova et al. use in vivo two-photon calcium imaging to record activity from cortical neurons of awake APPPS1 transgenic mice over four weeks, during the early phase of plaque deposition. They demonstrate that neuronal network pathology in models of cerebral amyloidosis is the consequence of persistent single cell aberrant neuronal activity, which could have diagnostic and therapeutic relevance for AD.