Effects of perioperative anesthetics on the postoperative prognosis of patients undergoing surgery for cervical cancer

Linyan Deng; Linyan Deng; Linyan Deng; Tingting Wang; Tingting Wang; Tingting Wang; Qiaofeng Zhang; Qiaofeng Zhang; Qiaofeng Zhang; Shaofang Shu; Shaofang Shu; Shaofang Shu; Xiangdong Chen; Xiangdong Chen; Xiangdong Chen

doi:10.3389/fphar.2025.1536663

Frontiers in Pharmacology (Mar 2025)

Effects of perioperative anesthetics on the postoperative prognosis of patients undergoing surgery for cervical cancer

Linyan Deng,
Linyan Deng,
Linyan Deng,
Tingting Wang,
Tingting Wang,
Tingting Wang,
Qiaofeng Zhang,
Qiaofeng Zhang,
Qiaofeng Zhang,
Shaofang Shu,
Shaofang Shu,
Shaofang Shu,
Xiangdong Chen,
Xiangdong Chen,
Xiangdong Chen

Affiliations

Linyan Deng: Department of Anesthesiology, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China
Linyan Deng: Institute of Anesthesia and Critical Care Medicine, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China
Linyan Deng: Key Laboratory of Anesthesiology and Resuscitation (Huazhong University of Science and Technology), Ministry of Education, Wuhan, China
Tingting Wang: Department of Anesthesiology, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China
Tingting Wang: Institute of Anesthesia and Critical Care Medicine, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China
Tingting Wang: Key Laboratory of Anesthesiology and Resuscitation (Huazhong University of Science and Technology), Ministry of Education, Wuhan, China
Qiaofeng Zhang: Department of Anesthesiology, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China
Qiaofeng Zhang: Institute of Anesthesia and Critical Care Medicine, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China
Qiaofeng Zhang: Key Laboratory of Anesthesiology and Resuscitation (Huazhong University of Science and Technology), Ministry of Education, Wuhan, China
Shaofang Shu: Department of Anesthesiology, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China
Shaofang Shu: Institute of Anesthesia and Critical Care Medicine, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China
Shaofang Shu: Key Laboratory of Anesthesiology and Resuscitation (Huazhong University of Science and Technology), Ministry of Education, Wuhan, China
Xiangdong Chen: Department of Anesthesiology, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China
Xiangdong Chen: Institute of Anesthesia and Critical Care Medicine, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China
Xiangdong Chen: Key Laboratory of Anesthesiology and Resuscitation (Huazhong University of Science and Technology), Ministry of Education, Wuhan, China

DOI: https://doi.org/10.3389/fphar.2025.1536663
Journal volume & issue: Vol. 16

Abstract

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Cervical cancer is a common malignancy among women, and tumor excision is the most common surgical intervention. Anesthetics used during surgery include general intravenous, volatile, local anesthetics, sedative and analgesic. Studies have shown that the selection of perioperative surgical methods and anesthetics may influence postoperative metastasis and cancer recurrence through their effects on the immune response and tumor cells. Therefore, the selection of perioperative anesthetic has a significant impact on patients undergoing surgery for cervical cancer. This study summarizes the effects and related mechanisms of common anesthetics on the prognosis of patients undergoing surgery for cervical cancer to provide a basis for developing more optimal anesthesia protocols.

Published in Frontiers in Pharmacology

ISSN: 1663-9812 (Online)
Publisher: Frontiers Media S.A.
Country of publisher: Switzerland
LCC subjects: Medicine: Therapeutics. Pharmacology
Website: http://journal.frontiersin.org/journals/pharmacology

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