A macrophage-specific lncRNA regulates apoptosis and atherosclerosis by tethering HuR in the nucleus

Viorel Simion; Haoyang Zhou; Stefan Haemmig; Jacob B. Pierce; Shanelle Mendes; Yevgenia Tesmenitsky; Daniel Pérez-Cremades; James F. Lee; Alex F. Chen; Nicoletta Ronda; Bianca Papotti; Jarrod A. Marto; Mark W. Feinberg

doi:10.1038/s41467-020-19664-2

Nature Communications (Dec 2020)

A macrophage-specific lncRNA regulates apoptosis and atherosclerosis by tethering HuR in the nucleus

Viorel Simion,
Haoyang Zhou,
Stefan Haemmig,
Jacob B. Pierce,
Shanelle Mendes,
Yevgenia Tesmenitsky,
Daniel Pérez-Cremades,
James F. Lee,
Alex F. Chen,
Nicoletta Ronda,
Bianca Papotti,
Jarrod A. Marto,
Mark W. Feinberg

Affiliations

Viorel Simion: Department of Medicine, Cardiovascular Division, Brigham and Women’s Hospital, Harvard Medical School
Haoyang Zhou: Department of Medicine, Cardiovascular Division, Brigham and Women’s Hospital, Harvard Medical School
Stefan Haemmig: Department of Medicine, Cardiovascular Division, Brigham and Women’s Hospital, Harvard Medical School
Jacob B. Pierce: Department of Medicine, Cardiovascular Division, Brigham and Women’s Hospital, Harvard Medical School
Shanelle Mendes: Department of Medicine, Cardiovascular Division, Brigham and Women’s Hospital, Harvard Medical School
Yevgenia Tesmenitsky: Department of Medicine, Cardiovascular Division, Brigham and Women’s Hospital, Harvard Medical School
Daniel Pérez-Cremades: Department of Medicine, Cardiovascular Division, Brigham and Women’s Hospital, Harvard Medical School
James F. Lee: The Blais Proteomics Center, Dana-Farber Cancer Institute
Alex F. Chen: Department of Cardiology, The Third Xiangya Hospital of Central South University
Nicoletta Ronda: Department of Food and Drug, University of Parma
Bianca Papotti: Department of Food and Drug, University of Parma
Jarrod A. Marto: The Blais Proteomics Center, Dana-Farber Cancer Institute
Mark W. Feinberg: Department of Medicine, Cardiovascular Division, Brigham and Women’s Hospital, Harvard Medical School

DOI: https://doi.org/10.1038/s41467-020-19664-2
Journal volume & issue: Vol. 11, no. 1
pp. 1 – 16

Abstract

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Long non coding RNA molecules have been implicated in the immunopathology of a range of inflammatory pathologies. Here the authors show lncRNA MAARS regulates apoptosis via interaction with HuR in the context of atherosclerosis.

Published in Nature Communications

ISSN: 2041-1723 (Online)
Publisher: Nature Portfolio
Country of publisher: United Kingdom
LCC subjects: Science
Website: https://www.nature.com/ncomms/

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