Normative dataset for plasma cytokines in healthy human adults
Yingkai Li,
John S. Yi,
Melissa A. Russo,
Marilyn Rosa-Bray,
Kent J. Weinhold,
Jeffrey T. Guptill
Affiliations
Yingkai Li
Neuromuscular Division, Department of Neurology, Duke University Medical Center, 915 S. LaSalle St. Ext.; Box 2926, SORF Building; Room 124, Durham, NC 27710, United States; Corresponding author.
John S. Yi
Department of Surgery, Duke University School of Medicine, Durham, NC 27710, United States
Melissa A. Russo
Neuromuscular Division, Department of Neurology, Duke University Medical Center, 915 S. LaSalle St. Ext.; Box 2926, SORF Building; Room 124, Durham, NC 27710, United States
Marilyn Rosa-Bray
Biomat USA–Grifols Plasma Operations, United States of America
Kent J. Weinhold
Department of Surgery, Duke University School of Medicine, Durham, NC 27710, United States
Jeffrey T. Guptill
Neuromuscular Division, Department of Neurology, Duke University Medical Center, 915 S. LaSalle St. Ext.; Box 2926, SORF Building; Room 124, Durham, NC 27710, United States; Duke Clinical Research Institute, Durham, NC 27710, United States
We determined normative data for plasma cytokines established from a cohort of 126 carefully screened healthy adults aged 18 to 64 years. Participants were enrolled to ensure an even age and sex distribution and to include at least 30% non-Caucasians. Plasma cytokines for 18 analytes were tested by multiplex immunoassay. The data are presented by age cohort (18–29 years, 30–39, 40–49, and 50–66), as well as by sex and racial background. This dataset complements published normative ranges of cellular subsets generated by comprehensive polychromatic flow cytometry analysis of the healthy human immune system [1]. These data are available to researchers and have value as a reference range for research involving peripheral cytokines.
