Nature Communications (Feb 2022)
Genetic associations with carotid intima-media thickness link to atherosclerosis with sex-specific effects in sub-Saharan Africans
- Palwende Romuald Boua,
- Jean-Tristan Brandenburg,
- Ananyo Choudhury,
- Hermann Sorgho,
- Engelbert A. Nonterah,
- Godfred Agongo,
- Gershim Asiki,
- Lisa Micklesfield,
- Solomon Choma,
- Francesc Xavier Gómez-Olivé,
- Scott Hazelhurst,
- Halidou Tinto,
- Nigel J. Crowther,
- Christopher G. Mathew,
- Michèle Ramsay,
- AWI-Gen Study,
- the H3Africa Consortium
Affiliations
- Palwende Romuald Boua
- Clinical Research Unit of Nanoro, Institut de Recherche en Sciences de la Santé, Centre national de la Recherche scientifique et technologique (CNRST)
- Jean-Tristan Brandenburg
- Sydney Brenner Institute for Molecular Bioscience, Faculty of Health Sciences, University of the Witwatersrand
- Ananyo Choudhury
- Sydney Brenner Institute for Molecular Bioscience, Faculty of Health Sciences, University of the Witwatersrand
- Hermann Sorgho
- Clinical Research Unit of Nanoro, Institut de Recherche en Sciences de la Santé, Centre national de la Recherche scientifique et technologique (CNRST)
- Engelbert A. Nonterah
- Navrongo Health Research Centre, Ghana Health Service
- Godfred Agongo
- Navrongo Health Research Centre, Ghana Health Service
- Gershim Asiki
- African Population and Health Research Center
- Lisa Micklesfield
- MRC/Wits Developmental Pathways for Health Research Unit, Faculty of Health Sciences, University of the Witwatersrand
- Solomon Choma
- Department of Pathology and Medical Sciences, University of Limpopo
- Francesc Xavier Gómez-Olivé
- MRC/Wits Rural Public Health and Health Transitions Research Unit (Agincourt), School of Public Health, Faculty of Health Sciences, University of the Witwatersrand
- Scott Hazelhurst
- School of Electrical and Information Engineering, University of the Witwatersrand
- Halidou Tinto
- Clinical Research Unit of Nanoro, Institut de Recherche en Sciences de la Santé, Centre national de la Recherche scientifique et technologique (CNRST)
- Nigel J. Crowther
- Department of Chemical Pathology, National Health Laboratory Service, Faculty of Health Sciences, University of the Witwatersrand
- Christopher G. Mathew
- Sydney Brenner Institute for Molecular Bioscience, Faculty of Health Sciences, University of the Witwatersrand
- Michèle Ramsay
- Sydney Brenner Institute for Molecular Bioscience, Faculty of Health Sciences, University of the Witwatersrand
- AWI-Gen Study
- the H3Africa Consortium
- DOI
- https://doi.org/10.1038/s41467-022-28276-x
- Journal volume & issue
-
Vol. 13,
no. 1
pp. 1 – 11
Abstract
Genetic studies of disease-relevant traits have mostly been performed on European populations. Here, the authors perform a genome-wide association study for carotid intima-media thickness, in sub-Saharan African samples, finding population-specific and sex-specific loci.
