Serum/glucocorticoid-inducible kinase 1 deficiency induces NLRP3 inflammasome activation and autoinflammation of macrophages in a murine endolymphatic hydrops model

Dao-Gong Zhang; Wen-Qian Yu; Jia-Hui Liu; Li-Gang Kong; Na Zhang; Yong-Dong Song; Xiao-Fei Li; Zhao-Min Fan; Ya-Feng Lyu; Na Li; Hai-Bo Wang

doi:10.1038/s41467-023-36949-4

Nature Communications (Mar 2023)

Serum/glucocorticoid-inducible kinase 1 deficiency induces NLRP3 inflammasome activation and autoinflammation of macrophages in a murine endolymphatic hydrops model

Dao-Gong Zhang,
Wen-Qian Yu,
Jia-Hui Liu,
Li-Gang Kong,
Na Zhang,
Yong-Dong Song,
Xiao-Fei Li,
Zhao-Min Fan,
Ya-Feng Lyu,
Na Li,
Hai-Bo Wang

Affiliations

Dao-Gong Zhang: Department of Otolaryngology-Head and Neck Surgery, Shandong Provincial ENT Hospital, Shandong University
Wen-Qian Yu: Department of Otolaryngology-Head and Neck Surgery, Shandong Provincial ENT Hospital, Shandong University
Jia-Hui Liu: Department of Otolaryngology-Head and Neck Surgery, Shandong Provincial ENT Hospital, Shandong University
Li-Gang Kong: Department of Otolaryngology-Head and Neck Surgery, Shandong Provincial ENT Hospital, Shandong University
Na Zhang: Department of Otolaryngology-Head and Neck Surgery, Shandong Provincial ENT Hospital, Shandong University
Yong-Dong Song: Department of Otolaryngology-Head and Neck Surgery, Shandong Provincial ENT Hospital, Shandong University
Xiao-Fei Li: Department of Otolaryngology-Head and Neck Surgery, Shandong Provincial ENT Hospital, Shandong University
Zhao-Min Fan: Department of Otolaryngology-Head and Neck Surgery, Shandong Provincial ENT Hospital, Shandong University
Ya-Feng Lyu: Department of Otolaryngology-Head and Neck Surgery, Shandong Provincial ENT Hospital, Shandong University
Na Li: Department of Otolaryngology-Head and Neck Surgery, Shandong Provincial ENT Hospital, Shandong University
Hai-Bo Wang: Department of Otolaryngology-Head and Neck Surgery, Shandong Provincial ENT Hospital, Shandong University

DOI: https://doi.org/10.1038/s41467-023-36949-4
Journal volume & issue: Vol. 14, no. 1
pp. 1 – 18

Abstract

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The immune response has been suggested to be involved in the pathology of Ménière’s disease. Here the authors implicate serum glucocorticoid-inducible kinase 1 as a regulator of the NLRP3 inflammasome and link to macrophage function in a model of Ménière’s disease pathology.

Published in Nature Communications

ISSN: 2041-1723 (Online)
Publisher: Nature Portfolio
Country of publisher: United Kingdom
LCC subjects: Science
Website: https://www.nature.com/ncomms/

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