Nature Communications (Feb 2018)
Characterizing steroid hormone receptor chromatin binding landscapes in male and female breast cancer
- Tesa M. Severson,
- Yongsoo Kim,
- Stacey E. P. Joosten,
- Karianne Schuurman,
- Petra van der Groep,
- Cathy B. Moelans,
- Natalie D. ter Hoeve,
- Quirine F. Manson,
- John W. Martens,
- Carolien H. M. van Deurzen,
- Ellis Barbe,
- Ingrid Hedenfalk,
- Peter Bult,
- Vincent T. H. B. M. Smit,
- Sabine C. Linn,
- Paul J. van Diest,
- Lodewyk Wessels,
- Wilbert Zwart
Affiliations
- Tesa M. Severson
- Division of Molecular Carcinogenesis, Oncode Institute, Netherlands Cancer Institute
- Yongsoo Kim
- Division of Molecular Carcinogenesis, Oncode Institute, Netherlands Cancer Institute
- Stacey E. P. Joosten
- Division of Oncogenomics, Oncode Institute, Netherlands Cancer Institute
- Karianne Schuurman
- Division of Oncogenomics, Oncode Institute, Netherlands Cancer Institute
- Petra van der Groep
- Department of Pathology, University Medical Center
- Cathy B. Moelans
- Department of Pathology, University Medical Center
- Natalie D. ter Hoeve
- Department of Pathology, University Medical Center
- Quirine F. Manson
- Department of Pathology, University Medical Center
- John W. Martens
- Dutch Breast Cancer Research Group, (BOOG Study Center)
- Carolien H. M. van Deurzen
- Dutch Breast Cancer Research Group, (BOOG Study Center)
- Ellis Barbe
- Dutch Breast Cancer Research Group, (BOOG Study Center)
- Ingrid Hedenfalk
- Division of Oncology and Pathology, Lund University
- Peter Bult
- Department of Pathology, Radboud University Medical Center
- Vincent T. H. B. M. Smit
- Dutch Breast Cancer Research Group, (BOOG Study Center)
- Sabine C. Linn
- Department of Pathology, University Medical Center
- Paul J. van Diest
- Department of Pathology, University Medical Center
- Lodewyk Wessels
- Division of Molecular Carcinogenesis, Oncode Institute, Netherlands Cancer Institute
- Wilbert Zwart
- Division of Oncogenomics, Oncode Institute, Netherlands Cancer Institute
- DOI
- https://doi.org/10.1038/s41467-018-02856-2
- Journal volume & issue
-
Vol. 9,
no. 1
pp. 1 – 12
Abstract
Male breast cancer (MBC) is rare and largely hormonally driven. Here, the authors examine the action of steroid hormone receptors in male and female breast cancers and find gender selective hormone receptor action that associates with the survival of MBC patients.
