Bacterial lipid droplets bind to DNA via an intermediary protein that enhances survival under stress

Congyan Zhang; Li Yang; Yunfeng Ding; Yang Wang; Lan Lan; Qin Ma; Xiang Chi; Peng Wei; Yongfang Zhao; Alexander Steinbüchel; Hong Zhang; Pingsheng Liu

doi:10.1038/ncomms15979

Nature Communications (Jul 2017)

Bacterial lipid droplets bind to DNA via an intermediary protein that enhances survival under stress

Congyan Zhang,
Li Yang,
Yunfeng Ding,
Yang Wang,
Lan Lan,
Qin Ma,
Xiang Chi,
Peng Wei,
Yongfang Zhao,
Alexander Steinbüchel,
Hong Zhang,
Pingsheng Liu

Affiliations

Congyan Zhang: National Laboratory of Biomacromolecules, CAS Center for Excellence in Biomacromolecules, Institute of Biophysics, Chinese Academy of Sciences
Li Yang: National Laboratory of Biomacromolecules, CAS Center for Excellence in Biomacromolecules, Institute of Biophysics, Chinese Academy of Sciences
Yunfeng Ding: National Laboratory of Biomacromolecules, CAS Center for Excellence in Biomacromolecules, Institute of Biophysics, Chinese Academy of Sciences
Yang Wang: National Laboratory of Biomacromolecules, CAS Center for Excellence in Biomacromolecules, Institute of Biophysics, Chinese Academy of Sciences
Lan Lan: National Laboratory of Biomacromolecules, CAS Center for Excellence in Biomacromolecules, Institute of Biophysics, Chinese Academy of Sciences
Qin Ma: University of Chinese Academy of Sciences
Xiang Chi: National Laboratory of Biomacromolecules, CAS Center for Excellence in Biomacromolecules, Institute of Biophysics, Chinese Academy of Sciences
Peng Wei: National Laboratory of Biomacromolecules, CAS Center for Excellence in Biomacromolecules, Institute of Biophysics, Chinese Academy of Sciences
Yongfang Zhao: National Laboratory of Biomacromolecules, CAS Center for Excellence in Biomacromolecules, Institute of Biophysics, Chinese Academy of Sciences
Alexander Steinbüchel: Institute of Molecular Microbiology and Biotechnology, University of Münster
Hong Zhang: National Laboratory of Biomacromolecules, CAS Center for Excellence in Biomacromolecules, Institute of Biophysics, Chinese Academy of Sciences
Pingsheng Liu: National Laboratory of Biomacromolecules, CAS Center for Excellence in Biomacromolecules, Institute of Biophysics, Chinese Academy of Sciences

DOI: https://doi.org/10.1038/ncomms15979
Journal volume & issue: Vol. 8, no. 1
pp. 1 – 15

Abstract

Read online

The MLDS protein is a major component of lipid droplets (LDs) in oleaginous bacteria. Here, Zhanget al. show that LDs bind to genomic DNA via MLDS, which enhances bacterial survival under certain stress conditions.

Published in Nature Communications

ISSN: 2041-1723 (Online)
Publisher: Nature Portfolio
Country of publisher: United Kingdom
LCC subjects: Science
Website: https://www.nature.com/ncomms/

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