The State of the Art of Natural Polymer Functionalized Fe<sub>3</sub>O<sub>4</sub> Magnetic Nanoparticle Composites for Drug Delivery Applications: A Review
Abu Hassan Nordin,
Zuliahani Ahmad,
Siti Muhamad Nur Husna,
Rushdan Ahmad Ilyas,
Ahmad Khusairi Azemi,
Noraznawati Ismail,
Muhammad Luqman Nordin,
Norzita Ngadi,
Nordin Hawa Siti,
Walid Nabgan,
Abd Samad Norfarhana,
Mohammad Saifulddin Mohd Azami
Affiliations
Abu Hassan Nordin
Faculty of Chemical and Energy Engineering, Universiti Teknologi Malaysia, Skudai 81310, Johor, Malaysia
Zuliahani Ahmad
Faculty of Applied Sciences, Universiti Teknologi MARA (UiTM), Arau 02600, Perlis, Malaysia
Siti Muhamad Nur Husna
Faculty of Applied Sciences, Universiti Teknologi MARA (UiTM), Arau 02600, Perlis, Malaysia
Rushdan Ahmad Ilyas
Faculty of Chemical and Energy Engineering, Universiti Teknologi Malaysia, Skudai 81310, Johor, Malaysia
Ahmad Khusairi Azemi
Institute of Marine Biotechnology, Universiti Malaysia Terengganu, Kuala Terengganu 21030, Terengganu, Malaysia
Noraznawati Ismail
Institute of Marine Biotechnology, Universiti Malaysia Terengganu, Kuala Terengganu 21030, Terengganu, Malaysia
Muhammad Luqman Nordin
Department of Clinical Studies, Faculty of Veterinary Medicine, Universiti Malaysia Kelantan, Pengkalan Chepa, Kota Bharu 16100, Kelantan, Malaysia
Norzita Ngadi
Faculty of Chemical and Energy Engineering, Universiti Teknologi Malaysia, Skudai 81310, Johor, Malaysia
Nordin Hawa Siti
Pharmacology Unit, School of Basic Medical Sciences, Faculty of Medicine, Universiti Sultan Zainal Abidin, Kuala Terengganu 20400, Terengganu, Malaysia
Walid Nabgan
Departament d’Enginyeria Química, Universitat Rovira I Virgili, Av. Països Catalans 26, 43007 Tarragona, Spain
Abd Samad Norfarhana
Faculty of Chemical and Energy Engineering, Universiti Teknologi Malaysia, Skudai 81310, Johor, Malaysia
Mohammad Saifulddin Mohd Azami
Faculty of Applied Sciences, Universiti Teknologi MARA (UiTM), Arau 02600, Perlis, Malaysia
Natural polymers have received a great deal of interest for their potential use in the encapsulation and transportation of pharmaceuticals and other bioactive compounds for disease treatment. In this perspective, the drug delivery systems (DDS) constructed by representative natural polymers from animals (gelatin and hyaluronic acid), plants (pectin and starch), and microbes (Xanthan gum and Dextran) are provided. In order to enhance the efficiency of polymers in DDS by delivering the medicine to the right location, reducing the medication’s adverse effects on neighboring organs or tissues, and controlling the medication’s release to stop the cycle of over- and under-dosing, the incorporation of Fe3O4 magnetic nanoparticles with the polymers has engaged the most consideration due to their rare characteristics, such as easy separation, superparamagnetism, and high surface area. This review is designed to report the recent progress of natural polymeric Fe3O4 magnetic nanoparticles in drug delivery applications, based on different polymers’ origins.
