Nature Communications (Mar 2018)
Genome-wide analysis yields new loci associating with aortic valve stenosis
- Anna Helgadottir,
- Gudmar Thorleifsson,
- Solveig Gretarsdottir,
- Olafur A. Stefansson,
- Vinicius Tragante,
- Rosa B. Thorolfsdottir,
- Ingileif Jonsdottir,
- Thorsteinn Bjornsson,
- Valgerdur Steinthorsdottir,
- Niek Verweij,
- Jonas B. Nielsen,
- Wei Zhou,
- Lasse Folkersen,
- Andreas Martinsson,
- Mahyar Heydarpour,
- Siddharth Prakash,
- Gylfi Oskarsson,
- Tomas Gudbjartsson,
- Arnar Geirsson,
- Isleifur Olafsson,
- Emil L. Sigurdsson,
- Peter Almgren,
- Olle Melander,
- Anders Franco-Cereceda,
- Anders Hamsten,
- Lars Fritsche,
- Maoxuan Lin,
- Bo Yang,
- Whitney Hornsby,
- Dongchuan Guo,
- Chad M. Brummett,
- Gonçalo Abecasis,
- Michael Mathis,
- Dianna Milewicz,
- Simon C. Body,
- Per Eriksson,
- Cristen J. Willer,
- Kristian Hveem,
- Christopher Newton-Cheh,
- J. Gustav Smith,
- Ragnar Danielsen,
- Gudmundur Thorgeirsson,
- Unnur Thorsteinsdottir,
- Daniel F. Gudbjartsson,
- Hilma Holm,
- Kari Stefansson
Affiliations
- Anna Helgadottir
- deCODE genetics/Amgen Inc.
- Gudmar Thorleifsson
- deCODE genetics/Amgen Inc.
- Solveig Gretarsdottir
- deCODE genetics/Amgen Inc.
- Olafur A. Stefansson
- deCODE genetics/Amgen Inc.
- Vinicius Tragante
- deCODE genetics/Amgen Inc.
- Rosa B. Thorolfsdottir
- deCODE genetics/Amgen Inc.
- Ingileif Jonsdottir
- deCODE genetics/Amgen Inc.
- Thorsteinn Bjornsson
- deCODE genetics/Amgen Inc.
- Valgerdur Steinthorsdottir
- deCODE genetics/Amgen Inc.
- Niek Verweij
- Department of Cardiology, University of Groningen, University Medical Center Groningen
- Jonas B. Nielsen
- Department of Internal Medicine, Division of Cardiovascular Medicine, University of Michigan
- Wei Zhou
- Department of Computational Medicine and Bioinformatics, University of Michigan
- Lasse Folkersen
- Cardiovascular Medicine Unit, Department of Medicine, Karolinska University Hospital Solna, Karolinska Institutet
- Andreas Martinsson
- Department of Cardiology, Clinical Sciences, Lund University and Skåne University Hospital
- Mahyar Heydarpour
- Department of Anesthesiology, Perioperative and Pain Medicine, Brigham and Women’s Hospital, 75 Francis Street
- Siddharth Prakash
- Department of Internal Medicine, Division of Medical Genetics, University of Texas Health Science Center at Houston
- Gylfi Oskarsson
- Childrens Hospital, Landspitali National University Hospital of Iceland
- Tomas Gudbjartsson
- Department of Surgery and Cardiothoracic Surgery, Landspitali National University Hospital
- Arnar Geirsson
- Section of Cardiac Surgery, Department of Surgery, Yale University School of Medicine
- Isleifur Olafsson
- Department of Clinical Biochemistry, Landspitali National University Hospital
- Emil L. Sigurdsson
- Heilsugaeslan Solvangi
- Peter Almgren
- Department of Clinical Sciences, Lund University
- Olle Melander
- Department of Clinical Sciences, Lund University
- Anders Franco-Cereceda
- Cardiothoracic Surgery Unit, Department of Molecular Medicine and Surgery, Karolinska University Hospital Solna, Karolinska Institutet
- Anders Hamsten
- Cardiovascular Medicine Unit, Department of Medicine, Karolinska University Hospital Solna, Karolinska Institutet
- Lars Fritsche
- HUNT Research Centre, Department of Public Health and General Practice, Norwegian University of Science and Technology
- Maoxuan Lin
- Department of Internal Medicine, Division of Cardiovascular Medicine, University of Michigan
- Bo Yang
- Department of Cardiac Surgery, University of Michigan
- Whitney Hornsby
- Frankel Cardiovascular Center, University of Michigan
- Dongchuan Guo
- Department of Internal Medicine, Division of Medical Genetics, University of Texas Health Science Center at Houston
- Chad M. Brummett
- Department of Anesthesiology, University of Michigan
- Gonçalo Abecasis
- Department of Biostatistics, University of Michigan
- Michael Mathis
- Department of Anesthesiology, University of Michigan
- Dianna Milewicz
- Department of Internal Medicine, Division of Medical Genetics, University of Texas Health Science Center at Houston
- Simon C. Body
- Department of Anesthesiology, Perioperative and Pain Medicine, Brigham and Women’s Hospital, 75 Francis Street
- Per Eriksson
- Cardiovascular Medicine Unit, Department of Medicine, Karolinska University Hospital Solna, Karolinska Institutet
- Cristen J. Willer
- Department of Internal Medicine, Division of Cardiovascular Medicine, University of Michigan
- Kristian Hveem
- HUNT Research Centre, Department of Public Health and General Practice, Norwegian University of Science and Technology
- Christopher Newton-Cheh
- Medical and Population Genetics Program, Broad Institute of MIT and Harvard
- J. Gustav Smith
- Department of Cardiology, Clinical Sciences, Lund University and Skåne University Hospital
- Ragnar Danielsen
- Faculty of Medicine, University of Iceland
- Gudmundur Thorgeirsson
- deCODE genetics/Amgen Inc.
- Unnur Thorsteinsdottir
- deCODE genetics/Amgen Inc.
- Daniel F. Gudbjartsson
- deCODE genetics/Amgen Inc.
- Hilma Holm
- deCODE genetics/Amgen Inc.
- Kari Stefansson
- deCODE genetics/Amgen Inc.
- DOI
- https://doi.org/10.1038/s41467-018-03252-6
- Journal volume & issue
-
Vol. 9,
no. 1
pp. 1 – 10
Abstract
Aortic valve stenosis (AS) is the most common valvular heart disease. Here the authors identify two new AS loci that also associate with bicuspid aortic valve, aortic root diameter and/or coronary artery disease implicating both developmental abnormalities and atherosclerosis-like processes in AS.
