Clinical and epidemiological round: journal club

Abstract

In this new edition of the Clinical and Epidemiologic Round, the reader will find four articles that we have considered of special relevance for current clinical practice. In a pragmatic, multicenter and randomized controlled trial, Myles et al compared a restrictive versus liberal intravenous-fluid strategy for patients undergoing major abdominal surgery evaluating disability-free survival after one year. Furthermore, Mørch et al, present a Danish prospective cohort evaluating the association between the use of oral contraceptives and risk of invasive breast cancer. Additionally, in a community-based cohort study, Lazarus et al aimed to quantify the association between metformin use and hospitalization with acidosis across the range of estimated glomerular filtration rate. At last, using a mendelian randomization study, Mountjoy et al aimed to determine whether more years spent in education is a causal risk factor for myopia or, conversely, whether myopia is a causal risk factor for more years in education.

Keywords

• Breast Neoplasms
• Chronic Kidney Disease
• Contraception
• Education
• Fluid Therapy
• Lactic Acidosis
• Metformin
• Myopia
• Postoperative Complications
• Risk Assessment
• Survival Rate