An atlas of endogenous DNA double-strand breaks arising during human neural cell fate determination

Abstract

Measurement(s) DNA Double Strand Break • Transcriptome • Whole Genome Sequencing • Chromosome conformation capture assay • Tumor Suppressor p53-Binding Protein 1 Technology Type(s) sBLISS - Genome-wide detection of DNA double-strand breaks by in-suspension breaks labeling in situ and sequencing • RNA-seq of total RNA • copy number variation profiling assay • Hi-C • Immunocytochemistry Factor Type(s) Human Neural Cell Fate Specification Sample Characteristic - Organism Homo sapiens Sample Characteristic - Environment cell culture