Nature Communications (Jan 2018)
Cellular stressors contribute to the expansion of hematopoietic clones of varying leukemic potential
- Terrence N. Wong,
- Christopher A. Miller,
- Matthew R. M. Jotte,
- Nusayba Bagegni,
- Jack D. Baty,
- Amy P. Schmidt,
- Amanda F. Cashen,
- Eric J. Duncavage,
- Nichole M. Helton,
- Mark Fiala,
- Robert S. Fulton,
- Sharon E. Heath,
- Megan Janke,
- Kierstin Luber,
- Peter Westervelt,
- Ravi Vij,
- John F. DiPersio,
- John S. Welch,
- Timothy A. Graubert,
- Matthew J. Walter,
- Timothy J. Ley,
- Daniel C. Link
Affiliations
- Terrence N. Wong
- Division of Oncology, Washington University School of Medicine
- Christopher A. Miller
- Division of Oncology, Washington University School of Medicine
- Matthew R. M. Jotte
- Division of Oncology, Washington University School of Medicine
- Nusayba Bagegni
- Division of Oncology, Washington University School of Medicine
- Jack D. Baty
- Division of Biostatistics, Washington University
- Amy P. Schmidt
- Division of Oncology, Washington University School of Medicine
- Amanda F. Cashen
- Division of Oncology, Washington University School of Medicine
- Eric J. Duncavage
- Department of Pathology and Immunology, Washington University School of Medicine
- Nichole M. Helton
- Division of Oncology, Washington University School of Medicine
- Mark Fiala
- Division of Oncology, Washington University School of Medicine
- Robert S. Fulton
- McDonnell Genome Institute, Washington University School of Medicine
- Sharon E. Heath
- Division of Oncology, Washington University School of Medicine
- Megan Janke
- Division of Oncology, Washington University School of Medicine
- Kierstin Luber
- Division of Oncology, Washington University School of Medicine
- Peter Westervelt
- Division of Oncology, Washington University School of Medicine
- Ravi Vij
- Division of Oncology, Washington University School of Medicine
- John F. DiPersio
- Division of Oncology, Washington University School of Medicine
- John S. Welch
- Division of Oncology, Washington University School of Medicine
- Timothy A. Graubert
- Massachusetts General Hospital
- Matthew J. Walter
- Division of Oncology, Washington University School of Medicine
- Timothy J. Ley
- Division of Oncology, Washington University School of Medicine
- Daniel C. Link
- Division of Oncology, Washington University School of Medicine
- DOI
- https://doi.org/10.1038/s41467-018-02858-0
- Journal volume & issue
-
Vol. 9,
no. 1
pp. 1 – 10
Abstract
Cellular stressors can impact clonal hematopoiesis. Here, the authors explore the impact of cytotoxic therapy and hematopoietic transplantation on clonal expansion, suggesting different stressors can promote expansion of distinct long-lived clones.
