Increased levels of thioredoxin and thioredoxin reductase in diabetic patients with coronary artery disease

Abstract

The prevalence of type 2 diabetes (DM) is considered an important risk factor for coronary artery disease (CAD). This study aimed to evaluate the relationship between CAD and thioredoxin (Trx) system and novel lipid indices in DM patients. In this case-control study, serum levels of Trx, Thioredoxin reductase (TrxR), Thioredoxin interacting protein (TXNIP), and novel lipid indices in DM undergoing coronary angiography (CAG) was investigated. A total of 99 patients with DM were included in the study (DM + CAD n: 62 and DM n: 37. Serum levels of intracellular antioxidant defense molecules, Trx and TrxR were significantly increased in patients with CAD+DM. However, TXNIP serum levels did not differ significantly between DM+CAD and DM groups. Also, there was a significant positive correlation between Trx and TXNIP (p [Med-Science 2021; 10(2.000): 391-5]

Keywords

• coronary artery disease
• thioredoxin interacting protein
• thioredoxin
• oxidative stress
• diabetes mellitus