Innate immune receptor signaling induces transient melanoma dedifferentiation while preserving immunogenicity

• Dirk Schadendorf,
• Antje Sucker,
• Johannes Koch,
• Fang Zhao,
• Susanne Horn,
• Beatrice Thier,
• Simone Stupia,
• Alicia Brüggemann,
• Nina Schulze,
• Christoph Coch,
• Gunther Hartmann,
• Annette Paschen

Affiliations

Dirk Schadendorf

Department of Dermatology, University Hospital of Essen, Essen, Germany

Antje Sucker

Dermatology, University Hospital Essen, Essen, Nordrhein-Westfalen, Germany

Johannes Koch

Department of Pediatrics, Paracelsus Medical University, Salzburg, Austria

Fang Zhao

Cambridge Institute for Medical Research, Addenbrooke`s Hospital, Cambridge, CB2 0XY, UK

Susanne Horn

Department of Dermatology, Venereology and Allergology, University Hospital Essen, Essen, Germany and German Cancer Consortium (DKTK) partner site Essen/Düsseldorf, Essen, Germany

Beatrice Thier

Department of Dermatology, University Hospital Essen, University of Duisburg-Essen, Essen, Germany

Simone Stupia

Department of Dermatology, University Hospital Essen, University of Duisburg-Essen, Essen, Germany

Alicia Brüggemann

Department of Dermatology, University Hospital Essen, University of Duisburg-Essen, Essen, Germany

Nina Schulze

Imaging Center Campus Essen, Center of Medical Biotechnology (ZMB), University of Duisburg-Essen, Essen, Germany

Christoph Coch

Institute of Clinical Chemistry and Clinical Pharmacology, University of Bonn, Bonn, Germany

Gunther Hartmann

Institute of Clinical Chemistry and Clinical Pharmacology, University of Bonn, Bonn, Germany

Annette Paschen

Department of Dermatology, University Hospital Essen, University of Duisburg-Essen, Essen, Germany