Exploring causal relationship between 41 inflammatory cytokines and marginal zone lymphoma: A bidirectional Mendelian randomization study

Hu Xinhang; Yu Fenglei; Peng Muyun; Yang Zhi; Ouyang Yifan; Zhang Zhe; Zhao Wangcheng; Yi Xuyang; Hu Huali; Huang Xingchun; Wang Li

doi:10.1515/med-2025-1171

Open Medicine (Apr 2025)

Exploring causal relationship between 41 inflammatory cytokines and marginal zone lymphoma: A bidirectional Mendelian randomization study

Hu Xinhang,
Yu Fenglei,
Peng Muyun,
Yang Zhi,
Ouyang Yifan,
Zhang Zhe,
Zhao Wangcheng,
Yi Xuyang,
Hu Huali,
Huang Xingchun,
Wang Li

Affiliations

Hu Xinhang: Department of Thoracic Surgery, The Second Xiangya Hospital, Central South University, Changsha, 410000, China
Yu Fenglei: Department of Thoracic Surgery, The Second Xiangya Hospital, Central South University, Changsha, 410000, China
Peng Muyun: Department of Thoracic Surgery, The Second Xiangya Hospital, Central South University, Changsha, 410000, China
Yang Zhi: Department of Thoracic Surgery, The Second Xiangya Hospital, Central South University, Changsha, 410000, China
Ouyang Yifan: Department of Thoracic Surgery, The Second Xiangya Hospital, Central South University, Changsha, 410000, China
Zhang Zhe: Department of Thoracic Surgery, The Second Xiangya Hospital, Central South University, Changsha, 410000, China
Zhao Wangcheng: Department of Thoracic Surgery, The Second Xiangya Hospital, Central South University, Changsha, 410000, China
Yi Xuyang: Department of Thoracic Surgery, The Second Xiangya Hospital, Central South University, Changsha, 410000, China
Hu Huali: Department of Thoracic Surgery, Hunan Rehabilitation Hospital, Changsha, 410000, China
Huang Xingchun: Department of Thoracic Surgery, The Second Xiangya Hospital, Central South University, Changsha, 410000, China
Wang Li: Department of Thoracic Surgery, The Second Xiangya Hospital, Central South University, Changsha, 410000, China

DOI: https://doi.org/10.1515/med-2025-1171
Journal volume & issue: Vol. 20, no. 1
pp. 639 – 56

Abstract

Read online

Marginal zone lymphoma (MZL) is a rare subtype of non-Hodgkin lymphoma, and its diagnosis primarily relies on pathological biopsy. The study aims to investigate the causal relationships between 41 inflammatory cytokines and MZL using a two-sample bidirectional Mendelian randomization (MR) approach, providing new insights and methodologies for rapid differential diagnosis and treatment strategies.

Published in Open Medicine

ISSN: 2391-5463 (Online)
Publisher: De Gruyter
Country of publisher: Poland
LCC subjects: Medicine
Website: https://www.degruyter.com/journal/key/med/html

About the journal

Abstract

Keywords