Functional and phylogenetic analysis of TetX variants to design a new classification system

Qipeng Cheng; Yanchu Cheung; Chenyu Liu; Edward Wai Chi Chan; Kwok Yin Wong; Rong Zhang; Sheng Chen

doi:10.1038/s42003-022-03465-y

Communications Biology (May 2022)

Functional and phylogenetic analysis of TetX variants to design a new classification system

Qipeng Cheng,
Yanchu Cheung,
Chenyu Liu,
Edward Wai Chi Chan,
Kwok Yin Wong,
Rong Zhang,
Sheng Chen

Affiliations

Qipeng Cheng: State Key Lab of Chemical Biology and Drug Discovery, Department of Applied Biology and Chemical Technology, The Hong Kong Polytechnic University
Yanchu Cheung: Department of Infectious Diseases and Public Health, Jockey Club College of Veterinary Medicine and Life Sciences, City University of Hong Kong
Chenyu Liu: Department of Infectious Diseases and Public Health, Jockey Club College of Veterinary Medicine and Life Sciences, City University of Hong Kong
Edward Wai Chi Chan: State Key Lab of Chemical Biology and Drug Discovery, Department of Applied Biology and Chemical Technology, The Hong Kong Polytechnic University
Kwok Yin Wong: State Key Lab of Chemical Biology and Drug Discovery, Department of Applied Biology and Chemical Technology, The Hong Kong Polytechnic University
Rong Zhang: Department of Clinical Laboratory, Second Affiliated Hospital of Zhejiang University, School of Medicine
Sheng Chen: Department of Infectious Diseases and Public Health, Jockey Club College of Veterinary Medicine and Life Sciences, City University of Hong Kong

DOI: https://doi.org/10.1038/s42003-022-03465-y
Journal volume & issue: Vol. 5, no. 1
pp. 1 – 9

Abstract

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TetX variants such as Tet(X3~14) were reported to confer resistance to tigecycline which is a last-resort antibiotic used to treat infections caused by multidrug-resistant bacteria. Here, Cheng et al. propose a new classification system for TetX variants.

Published in Communications Biology

ISSN: 2399-3642 (Online)
Publisher: Nature Portfolio
Country of publisher: United Kingdom
LCC subjects: Science: Biology (General)
Website: https://www.nature.com/commsbio/

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