Multi-objective structural optimization and degradation model of magnesium alloy ureteral stent

Abstract

Background: Mg alloys have attractive properties, including biocompatibility, biodegradability, and ideal mechanical properties. Moreover, Mg alloys are regarded as one of the promising candidates for manufacturing ureteral stents. This study proposed a multi-objective optimization method based on the Kriging surrogate model, NSGA-Ⅲ, and finite element analysis to improve the degradation performance of Mg alloy ureteral stents. Methods: The finite element model for the degradation of Mg alloy ureteral stents has been established to compare the degradation performance of the stents under different parameters. Latin hypercube sampling was adopted to generate train sample points in the design space. Meanwhile, the Kriging surrogate model was constructed between strut parameters and stent degradation behavior. The NSGA-Ⅲ was utilized to determine the optimal solution in the global design space. Results: The optimized stent achieved 5.52 ​× ​degradation uniformity (M), 10 ​× ​degradation time (DT), and 4 ​× ​work time (FT). The errors between the Kriging surrogate model and the finite element calculation results were less than 6%. Conclusion: The optimized stent achieved better degradation performance. The degradation behavior of stents was dependent on the design parameters. The multi-objective optimization method based on the Kriging surrogate model and finite element analysis was effective in stent design optimization problems.

Keywords

• Mg alloys ureteral stent
• Kriging surrogate model
• NSGA-Ⅲ
• Multi-objective optimization
• Degradation model