IMMUNOLOGICAL PARAMETERS, FUNCTIONAL AND METABOLIC ACTIVITY OF BLOOD NEUTROPHILS IN PATIENTS WITH BASAL CELL SKIN CARCINOMA

Abstract

Abstract. Twenty patients with basal cell skin carcinoma at the age of 56 to 70 years have been included into study. We have investigated multiple parameters of cellular and humoral immunity, features of phagocytic activity, spontaneous and stimulated chemiluminescence of peripheral blood neutrophils. Distinct changes in blood lymphocyte subsets have been assessed by immunophenotyping. Changes in serum immunoglobulin profiles and increased levels of circulating immune complexes were revealed. Altered phagocytic activity and oxygen-dependent metabolism of blood neutrophils were also detected.

Keywords

• immunity
• phagocytosis
• chemiluminescence
• basal cell skin cancer