Psoriasis: Targets and Therapy (Jun 2011)
Editorial
Abstract
Jerry BagelPsoriasis Treatment Center of Central New Jersey, East Windsor, NJ, USATwenty-five years ago, inpatient Goekerman therapy was considered to be the "gold standard" treatment for psoriasis. We thought PUVA (psoralen + ultraviolet A light) worked because it intercalated keratinocytes inhibiting cell division, methotrexate affected keratinocytic proliferation, and broadband ultraviolet B creating thymine dimers which also prevented keratinocytic proliferation. The idea that psoriasis was an immunologic disease was in its embryonic development.