Nature Communications (Jan 2018)

Peptidomimetic blockade of MYB in acute myeloid leukemia

  • Kavitha Ramaswamy,
  • Lauren Forbes,
  • Gerard Minuesa,
  • Tatyana Gindin,
  • Fiona Brown,
  • Michael G. Kharas,
  • Andrei V. Krivtsov,
  • Scott A. Armstrong,
  • Eric Still,
  • Elisa de Stanchina,
  • Birgit Knoechel,
  • Richard Koche,
  • Alex Kentsis

DOI
https://doi.org/10.1038/s41467-017-02618-6
Journal volume & issue
Vol. 9, no. 1
pp. 1 – 13

Abstract

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MYB activity is a key factor for the maintenance of acute myeloid leukemias but it is also a difficult target. Here, the authors develop a peptidomimetic (MYBMIM) that prevents the interaction of the trans-activation domain of MYB with the KIX domain of CBP/P300 and inhibits leukaemia growth.