Pteridines
(Oct 2020)
Folate-targeted PTEN/AKT/P53 signaling pathway promotes apoptosis in breast cancer cells
Wang Hexian,
Fan Qiang,
Zhang Longlong,
Shi Danli,
Wang Haibo,
Wang Shoulian,
Bian Bangjian
Affiliations
Wang Hexian
Shanghai Jiao Tong University School of Medicine, Shanghai, China
Fan Qiang
Department of General Surgery, Shanghai 9th People’s Hospital Shanghai Jiao Tong University School of Medicine, Shanghai, China
Zhang Longlong
Department of General Surgery, Shanghai 9th People’s Hospital Shanghai Jiao Tong University School of Medicine, Shanghai, China
Shi Danli
Department of General Surgery, Shanghai 9th People’s Hospital Shanghai Jiao Tong University School of Medicine, Shanghai, China
Wang Haibo
Department of General Surgery, Shanghai 9th People’s Hospital Shanghai Jiao Tong University School of Medicine, Shanghai, China
Wang Shoulian
Department of General Surgery, Shanghai 9th People’s Hospital Shanghai Jiao Tong University School of Medicine, Shanghai, China
Bian Bangjian
Department of General Surgery, Shanghai 9th People’s Hospital Shanghai Jiao Tong University School of Medicine, Shanghai, China
DOI
https://doi.org/10.1515/pteridines-2020-0020
Journal volume & issue
Vol. 31,
no. 1
Abstract
Read online
Objective Folate deficiency is closely related to the occurrence of human tumors and plays an important role in cell growth, differentiation, repair, and host defense. We studied the effects of folic acid on the apoptosis of breast cancer cells (MDA-MB-231) and on the activity of the PTEN/AKT/P53 signaling pathway in breast cancer cells.
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