Optimal control applied to community-acquired methicillin-resistant Staphylococcus aureus in hospitals

Abstract

Optimal control methods are applied to a deterministic mathematical model to characterize the factors contributing to the replacement of hospital-acquired methicillin-resistant Staphylococcus aureus (HA-MRSA) with community-acquired methicillin-resistant Staphylococcus aureus (CA-MRSA), and quantify the effectiveness of three interventions aimed at limiting the spread of CA-MRSA in healthcare settings. Characterizations of the optimal control strategies are established, and numerical simulations are provided to illustrate the results.

Keywords

• Optimal control
• MRSA
• decolonization
• screening