Cryo-EM fibril structures from systemic AA amyloidosis reveal the species complementarity of pathological amyloids

Falk Liberta; Sarah Loerch; Matthies Rennegarbe; Angelika Schierhorn; Per Westermark; Gunilla T. Westermark; Bouke P. C. Hazenberg; Nikolaus Grigorieff; Marcus Fändrich; Matthias Schmidt

doi:10.1038/s41467-019-09033-z

Nature Communications (Mar 2019)

Cryo-EM fibril structures from systemic AA amyloidosis reveal the species complementarity of pathological amyloids

Falk Liberta,
Sarah Loerch,
Matthies Rennegarbe,
Angelika Schierhorn,
Per Westermark,
Gunilla T. Westermark,
Bouke P. C. Hazenberg,
Nikolaus Grigorieff,
Marcus Fändrich,
Matthias Schmidt

Affiliations

Falk Liberta: Institute of Protein Biochemistry, Ulm University
Sarah Loerch: Janelia Research Campus, Howard Hughes Medical Institute
Matthies Rennegarbe: Institute of Protein Biochemistry, Ulm University
Angelika Schierhorn: Institute of Biochemistry and Biotechnology, Martin-Luther-University
Per Westermark: Department of Immunology, Genetics, and Pathology, Uppsala University
Gunilla T. Westermark: Department of Medical Cell Biology, Uppsala University
Bouke P. C. Hazenberg: Department of Rheumatology & Clinical Immunology, University of Groningen, University Medical Center Groningen
Nikolaus Grigorieff: Janelia Research Campus, Howard Hughes Medical Institute
Marcus Fändrich: Institute of Protein Biochemistry, Ulm University
Matthias Schmidt: Institute of Protein Biochemistry, Ulm University

DOI: https://doi.org/10.1038/s41467-019-09033-z
Journal volume & issue: Vol. 10, no. 1
pp. 1 – 10

Abstract

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Systemic AA amyloidosis is caused by misfolding of the acute phase protein serum amyloid A1. Here the authors present the cryo-EM structures of murine and human AA amyloid fibrils that were isolated from tissue samples and describe how the fibrils differ in their fundamental structural properties.

Published in Nature Communications

ISSN: 2041-1723 (Online)
Publisher: Nature Portfolio
Country of publisher: United Kingdom
LCC subjects: Science
Website: https://www.nature.com/ncomms/

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