The Fungal and Bacterial Interface in the Respiratory Mycobiome with a Focus on <i>Aspergillus</i> spp.
Anna Rozaliyani,
Budhi Antariksa,
Fariz Nurwidya,
Jamal Zaini,
Findra Setianingrum,
Firman Hasan,
Husna Nugrahapraja,
Humaira Yusva,
Heri Wibowo,
Anom Bowolaksono,
Chris Kosmidis
Affiliations
Anna Rozaliyani
Department of Parasitology, Faculty of Medicine, Universitas Indonesia, Jakarta 10430, Indonesia
Budhi Antariksa
Department of Pulmonoloy and Respiratory Medicine, Faculty of Medicinie, Universitas Indonesia, Persahabatan National Respiratory Referral Hospital, Jakarta 13230, Indonesia
Fariz Nurwidya
Department of Pulmonoloy and Respiratory Medicine, Faculty of Medicinie, Universitas Indonesia, Persahabatan National Respiratory Referral Hospital, Jakarta 13230, Indonesia
Jamal Zaini
Department of Pulmonoloy and Respiratory Medicine, Faculty of Medicinie, Universitas Indonesia, Persahabatan National Respiratory Referral Hospital, Jakarta 13230, Indonesia
Findra Setianingrum
Department of Parasitology, Faculty of Medicine, Universitas Indonesia, Jakarta 10430, Indonesia
Firman Hasan
Indonesia Pulmonary Mycoses Centre, Jakarta 10430, Indonesia
Husna Nugrahapraja
Life Science and Biotechnology, Bandung Institute of Technology, Bandung 40312, Indonesia
Humaira Yusva
Magister Program of Biomedical Sciences, Faculty of Medicine, Universitas Indonesia, Jakarta 10430, Indonesia
Heri Wibowo
Department of Parasitology, Faculty of Medicine, Universitas Indonesia, Jakarta 10430, Indonesia
Anom Bowolaksono
Department of Biology, Faculty of Mathematics and Natural Sciences (FMIPA), Universitas Indonesia, Depok 16424, Indonesia
Chris Kosmidis
Manchester Academic Health Science Centre, Division of Infection, Immunity and Respiratory Medicine, Faculty of Biology, Medicine and Health, University of Manchester, Manchester M23 9LT, UK
The heterogeneity of the lung microbiome and its alteration are prevalently seen among chronic lung diseases patients. However, studies to date have primarily focused on the bacterial microbiome in the lung rather than fungal composition, which might play an essential role in the mechanisms of several chronic lung diseases. It is now well established that Aspergillus spp. colonies may induce various unfavorable inflammatory responses. Furthermore, bacterial microbiomes such as Pseudomonas aeruginosa provide several mechanisms that inhibit or stimulate Aspergillus spp. life cycles. In this review, we highlighted fungal and bacterial microbiome interactions in the respiratory tract, with a focus on Aspergillus spp.
