Effects of accommodation on geometrical parameters of human lens: A systematic review and meta-analysis
Guanghong Zhang,
Jun Jiang,
Qian Wei,
Chao Qu
Affiliations
Guanghong Zhang
Department of Ophthalmology, Sichuan Provincial People's Hospital, University of Electronic Science and Technology of China, No. 2006, Xiyuan Ave West Hi-Tech Zone, Chengdu, CN 611731, China; School of Medicine, University of Electronic Science and Technology of China, No. 2006, Xiyuan Ave West Hi-Tech Zone, Chengdu, CN 611731, China; Sichuan Key Laboratory for Disease Gene Study, Chinese Academy of Sciences Sichuan Translational Medicine Research Hospital, No. 32 of the West 2nd Section of First Ring Road, Chengdu 610072, China
Jun Jiang
Department of Ophthalmology, Sichuan Provincial People's Hospital, University of Electronic Science and Technology of China, No. 2006, Xiyuan Ave West Hi-Tech Zone, Chengdu, CN 611731, China; School of Medicine, University of Electronic Science and Technology of China, No. 2006, Xiyuan Ave West Hi-Tech Zone, Chengdu, CN 611731, China; Sichuan Key Laboratory for Disease Gene Study, Chinese Academy of Sciences Sichuan Translational Medicine Research Hospital, No. 32 of the West 2nd Section of First Ring Road, Chengdu 610072, China
Qian Wei
Southwest Medical University, No. 319, Section 3, Zhongshan Road, Luzhou 646000, China
Chao Qu
Department of Ophthalmology, Sichuan Provincial People's Hospital, University of Electronic Science and Technology of China, No. 2006, Xiyuan Ave West Hi-Tech Zone, Chengdu, CN 611731, China; School of Medicine, University of Electronic Science and Technology of China, No. 2006, Xiyuan Ave West Hi-Tech Zone, Chengdu, CN 611731, China; Sichuan Key Laboratory for Disease Gene Study, Chinese Academy of Sciences Sichuan Translational Medicine Research Hospital, No. 32 of the West 2nd Section of First Ring Road, Chengdu 610072, China; Corresponding author. Department of Ophthalmology, Sichuan Provincial People's Hospital, University of Electronic Science and Technology of China No. 2006, Xiyuan Ave West Hi-Tech Zone, Chengdu, CN 611731, China.
Purpose: To investigate the effects of accommodation on the geometrical parameters of human lens. Methods: Eight databases from inception to November 2023 were used for the literature search: CNKI, CBM, VIP, Wan-Fang, PubMed, Web of Science, EMBASE, and the Cochrane Library. The Methodological Index for Non-randomized Studies was used to assess the risk of bias. The PRISMA were followed and the following outcomes were taken into consideration: lens diameter (LD), lens thickness (LT), anterior curvature radius (ACR), posterior curvature radius (PCR), lens center position (LCP), and total cross-sectional area (TCSA). This systematic review was registered on an international platform for registered systematic reviews and meta-analysis (INPLASY202260085). Results: A total of 19 studies were included. LT increased by 0.04 mm/D (18 studies; 95% confidence interval [CI], 0.03–0.06; I2 = 96.6%; P < 0.001). At the same time, LD, ACR, and PCR decreased by 0.06 mm/D (6 studies; 95%CI, −0.07–0.05; I2 = 50.1%; P < 0.001), 0.53 mm/D (8 studies; 95%CI, −0.64–0.41; I2 = 96.5%; P < 0.001), and 0.14 mm/D (9 studies; 95%CI, −0.19–0.09; I2 = 94.7%; P < 0.001) during accommodation, respectively. Moreover, LCP shifted forward by 0.01 mm/D (3 studies; 95%CI, −0.02–0.00; I2 = 0.0%; P < 0.001), and TCSA by 0.58 mm2/D (2 studies; 95%CI, 0.41–1.57; I2 = 97.0%; P = 0.457) during accommodation. Conclusions: Changes in LT, LD, ACR, PCR and LCP supported Helmholtz's theory. Different apparatuses or measurement methods influenced the measurement of lens geometrical parameters.
