Age- and sex-dependent reference intervals for uric acid estimated by the truncated minimum chi-square (TMC) approach, a new indirect method

Abstract

Although the concentration of uric acid in serum or plasma is known to depend on sex and age and is subject to diurnal variation, the influence of these covariates on the reference interval (RI) is often neglected. Consequently, the values in the literature vary considerably. Therefore, we reinvestigated the reference limits and their dependence on covariates.

Keywords

• age and sex dependency
• reference intervals
• uric acid