Nature Communications (Nov 2022)
Thiocarbazate building blocks enable the construction of azapeptides for rapid development of therapeutic candidates
- Ahmad Altiti,
- Mingzhu He,
- Sonya VanPatten,
- Kai Fan Cheng,
- Umair Ahmed,
- Pui Yan Chiu,
- Ibrahim T. Mughrabi,
- Bayan Al Jabari,
- Ronald M. Burch,
- Kirk R. Manogue,
- Kevin J. Tracey,
- Betty Diamond,
- Christine N. Metz,
- Huan Yang,
- LaQueta K. Hudson,
- Stavros Zanos,
- Myoungsun Son,
- Barbara Sherry,
- Thomas R. Coleman,
- Yousef Al-Abed
Affiliations
- Ahmad Altiti
- Institute of Bioelectronic Medicine, Feinstein Institutes for Medical Research, Northwell Health
- Mingzhu He
- Institute of Bioelectronic Medicine, Feinstein Institutes for Medical Research, Northwell Health
- Sonya VanPatten
- Institute of Bioelectronic Medicine, Feinstein Institutes for Medical Research, Northwell Health
- Kai Fan Cheng
- Institute of Bioelectronic Medicine, Feinstein Institutes for Medical Research, Northwell Health
- Umair Ahmed
- Institute of Bioelectronic Medicine, Feinstein Institutes for Medical Research, Northwell Health
- Pui Yan Chiu
- Institute of Molecular Medicine, Feinstein Institutes for Medical Research
- Ibrahim T. Mughrabi
- Institute of Bioelectronic Medicine, Feinstein Institutes for Medical Research, Northwell Health
- Bayan Al Jabari
- Institute of Bioelectronic Medicine, Feinstein Institutes for Medical Research, Northwell Health
- Ronald M. Burch
- Applied Immunotherapeutics, Inc
- Kirk R. Manogue
- Center for Molecular Innovation, Feinstein Institutes for Medical Research
- Kevin J. Tracey
- Institute of Bioelectronic Medicine, Feinstein Institutes for Medical Research, Northwell Health
- Betty Diamond
- Institute of Molecular Medicine, Feinstein Institutes for Medical Research
- Christine N. Metz
- Institute of Molecular Medicine, Feinstein Institutes for Medical Research
- Huan Yang
- Institute of Bioelectronic Medicine, Feinstein Institutes for Medical Research, Northwell Health
- LaQueta K. Hudson
- Donald and Barbara Zucker School of Medicine at Hofstra/Northwell
- Stavros Zanos
- Institute of Bioelectronic Medicine, Feinstein Institutes for Medical Research, Northwell Health
- Myoungsun Son
- Institute of Molecular Medicine, Feinstein Institutes for Medical Research
- Barbara Sherry
- Institute of Molecular Medicine, Feinstein Institutes for Medical Research
- Thomas R. Coleman
- Center for Molecular Innovation, Feinstein Institutes for Medical Research
- Yousef Al-Abed
- Institute of Bioelectronic Medicine, Feinstein Institutes for Medical Research, Northwell Health
- DOI
- https://doi.org/10.1038/s41467-022-34712-9
- Journal volume & issue
-
Vol. 13,
no. 1
pp. 1 – 13
Abstract
The rapid protease degradation of peptides is currently limiting their therapeutic utility. Here, the authors report functionalised thiocarbazate scaffolds as precursors of aza-amino acids that can be integrated in peptide sequences, extending their bioavailability, and demonstrate this on FSSE/P5779 and bradykinin.
