Nature Communications (Feb 2022)
Targeting ferroptosis protects against experimental (multi)organ dysfunction and death
- Samya Van Coillie,
- Emily Van San,
- Ines Goetschalckx,
- Bartosz Wiernicki,
- Banibrata Mukhopadhyay,
- Wulf Tonnus,
- Sze Men Choi,
- Ria Roelandt,
- Catalina Dumitrascu,
- Ludwig Lamberts,
- Geert Dams,
- Wannes Weyts,
- Jelle Huysentruyt,
- Behrouz Hassannia,
- Irina Ingold,
- Suhas Lele,
- Evelyne Meyer,
- Maya Berg,
- Ruth Seurinck,
- Yvan Saeys,
- An Vermeulen,
- Alexander L. N. van Nuijs,
- Marcus Conrad,
- Andreas Linkermann,
- Mohan Rajapurkar,
- Peter Vandenabeele,
- Eric Hoste,
- Koen Augustyns,
- Tom Vanden Berghe
Affiliations
- Samya Van Coillie
- VIB-UGent Center for Inflammation Research
- Emily Van San
- VIB-UGent Center for Inflammation Research
- Ines Goetschalckx
- Department of Biomedical Sciences, University of Antwerp
- Bartosz Wiernicki
- VIB-UGent Center for Inflammation Research
- Banibrata Mukhopadhyay
- Department of Nephrology, Muljibhai Patel Society for Research in Nephro-Urology
- Wulf Tonnus
- Department of Internal Medicine 3, University Hospital Carl Gustav Carus, the Technische Universität Dresden
- Sze Men Choi
- VIB-UGent Center for Inflammation Research
- Ria Roelandt
- VIB-UGent Center for Inflammation Research
- Catalina Dumitrascu
- Department of Pharmaceutical Sciences, Toxicological Centre, University of Antwerp
- Ludwig Lamberts
- Department of Biomedical Sciences, University of Antwerp
- Geert Dams
- Department of Biomedical Sciences, University of Antwerp
- Wannes Weyts
- VIB-UGent Center for Medical Biotechnology
- Jelle Huysentruyt
- VIB-UGent Center for Inflammation Research
- Behrouz Hassannia
- VIB-UGent Center for Inflammation Research
- Irina Ingold
- Institute of Metabolism and Cell Death, Helmholtz Zentrum München, German Research Center for Environmental Health
- Suhas Lele
- Department of Nephrology, Muljibhai Patel Society for Research in Nephro-Urology
- Evelyne Meyer
- Department of Pharmacology, Toxicology and Biochemistry, Ghent University
- Maya Berg
- Department of Pharmaceutical Sciences, Toxicological Centre, University of Antwerp
- Ruth Seurinck
- VIB-UGent Center for Inflammation Research
- Yvan Saeys
- VIB-UGent Center for Inflammation Research
- An Vermeulen
- Department of Bioanalysis, Ghent University
- Alexander L. N. van Nuijs
- Department of Pharmaceutical Sciences, Toxicological Centre, University of Antwerp
- Marcus Conrad
- Institute of Metabolism and Cell Death, Helmholtz Zentrum München, German Research Center for Environmental Health
- Andreas Linkermann
- Department of Internal Medicine 3, University Hospital Carl Gustav Carus, the Technische Universität Dresden
- Mohan Rajapurkar
- Department of Nephrology, Muljibhai Patel Society for Research in Nephro-Urology
- Peter Vandenabeele
- VIB-UGent Center for Inflammation Research
- Eric Hoste
- Intensive Care Unit, Ghent University Hospital; Ghent University
- Koen Augustyns
- Department of Pharmaceutical Sciences, Toxicological Centre, University of Antwerp
- Tom Vanden Berghe
- VIB-UGent Center for Inflammation Research
- DOI
- https://doi.org/10.1038/s41467-022-28718-6
- Journal volume & issue
-
Vol. 13,
no. 1
pp. 1 – 14
Abstract
Catalytic iron is associated with intensive care unit mortality and is known to cause free radical-mediated cellular toxicity. Here the authors show that a soluble ferrostatin-analogue (a ferroptosis inhibitor) protects mice from injury and death in experimental iron overload induced and genetic models of organ dysfunction, but not sepsis-induced multiorgan dysfunction.
