Neurotoxic Side Effects of Antimicrobial and Anti-Tuberculosis Drugs

Abstract

The literature data on the frequency and manifestations of neurotoxic effects of a number of antimicrobial drugs on the central and peripheral nervous system are analyzed. The predisposing factors for the development of neurotoxicity and risk groups are identified. The mechanisms of the neurotoxic action of fluoroquinolones, aminoglycosides, oxazolidinones, and a number of anti-tuberculosis drugs are described. Particular attention is paid to anti-tuberculosis drugs due to the need for the complex use of several drugs with a similar safety profile. The necessity of early detection of neurotoxicity of drugs and complex regimens for minimization of side effects, timely correction, and full treatment of patients has been substantiated.

Keywords

• antimicrobial drugs
• anti-tuberculosis drugs
• unwanted side effects
• neurotoxicity
• mechanisms of neurotoxicity