Detection of Alzheimer Disease on Online Handwriting Using 1D Convolutional Neural Network

Abstract

Building upon the recent advances and successes in the application of deep learning to the medical field, we propose in this work a new approach to detect and classify early-stage Alzheimer patients using online handwriting (HW) loop patterns. To cope with the lack of training data prevalent in the tasks of classification of neuro-degenerative diseases from behavioral data, we investigate several data augmentation techniques. In this respect, compared to the traditional data augmentation techniques proposed for HW-based Parkinson detection, we investigate a variant of Generative Adversarial Networks (GANs), DoppelGANger, especially tailored for times series and hence suitable for synthesizing realistic online handwriting sequences. Based on a 1D-Convolutional Neural Network (1D-CNN) to perform Alzheimer classification, we show, on a real dataset related to HW and Alzheimer, that our DoppelGANger-based augmentation model allow the CNN to significantly outperform both the current state of the art and the other data augmentation techniques.

Keywords

• Alzheimer disease
• DoppelGANger
• online handwriting
• 1D-convolution neural networks