Substrate binding in the mitochondrial ADP/ATP carrier is a step-wise process guiding the structural changes in the transport cycle

Vasiliki Mavridou; Martin S. King; Sotiria Tavoulari; Jonathan J. Ruprecht; Shane M. Palmer; Edmund R. S. Kunji

doi:10.1038/s41467-022-31366-5

Nature Communications (Jun 2022)

Substrate binding in the mitochondrial ADP/ATP carrier is a step-wise process guiding the structural changes in the transport cycle

Vasiliki Mavridou,
Martin S. King,
Sotiria Tavoulari,
Jonathan J. Ruprecht,
Shane M. Palmer,
Edmund R. S. Kunji

Affiliations

Vasiliki Mavridou: Medical Research Council Mitochondrial Biology Unit, University of Cambridge, Cambridge Biomedical Campus, Keith Peters Building
Martin S. King: Medical Research Council Mitochondrial Biology Unit, University of Cambridge, Cambridge Biomedical Campus, Keith Peters Building
Sotiria Tavoulari: Medical Research Council Mitochondrial Biology Unit, University of Cambridge, Cambridge Biomedical Campus, Keith Peters Building
Jonathan J. Ruprecht: Medical Research Council Mitochondrial Biology Unit, University of Cambridge, Cambridge Biomedical Campus, Keith Peters Building
Shane M. Palmer: Medical Research Council Mitochondrial Biology Unit, University of Cambridge, Cambridge Biomedical Campus, Keith Peters Building
Edmund R. S. Kunji: Medical Research Council Mitochondrial Biology Unit, University of Cambridge, Cambridge Biomedical Campus, Keith Peters Building

DOI: https://doi.org/10.1038/s41467-022-31366-5
Journal volume & issue: Vol. 13, no. 1
pp. 1 – 12

Abstract

Read online

The mitochondrial ADP/ATP carrier transports adenine nucleotides. Here, authors identify the residues involved in substrate binding. One set forms the central substrate binding site and two asparagine/arginine pairs help to guide the substrates during the transport cycle.

Published in Nature Communications

ISSN: 2041-1723 (Online)
Publisher: Nature Portfolio
Country of publisher: United Kingdom
LCC subjects: Science
Website: https://www.nature.com/ncomms/

About the journal