Catalytic synthesis of new pyrazolo [3,4-b] pyridine via a cooperative vinylogous anomeric-based oxidation

Hassan Sepehrmansourie; Mahmoud Zarei; Mohammad Ali Zolfigol; Saeed Babaee; Saeid Azizian; Sadegh Rostamnia

doi:10.1038/s41598-022-17879-5

Scientific Reports (Aug 2022)

Catalytic synthesis of new pyrazolo [3,4-b] pyridine via a cooperative vinylogous anomeric-based oxidation

Hassan Sepehrmansourie,
Mahmoud Zarei,
Mohammad Ali Zolfigol,
Saeed Babaee,
Saeid Azizian,
Sadegh Rostamnia

Affiliations

Hassan Sepehrmansourie: Department of Organic Chemistry, Faculty of Chemistry, Bu-Ali Sina University
Mahmoud Zarei: Department of Organic Chemistry, Faculty of Chemistry, Bu-Ali Sina University
Mohammad Ali Zolfigol: Department of Organic Chemistry, Faculty of Chemistry, Bu-Ali Sina University
Saeed Babaee: Department of Organic Chemistry, Faculty of Chemistry, Bu-Ali Sina University
Saeid Azizian: Department of Physical Chemistry, Faculty of Chemistry, Bu-Ali Sina University
Sadegh Rostamnia: Organic and Nano Group (ONG), Department of Chemistry, Iran University of Science and Technology (IUST)

DOI: https://doi.org/10.1038/s41598-022-17879-5
Journal volume & issue: Vol. 12, no. 1
pp. 1 – 15

Abstract

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Abstract In this study, a novel nano-magnetic metal–organic frameworks based on Fe3O4 namely Fe3O4@MIL-101(Cr)-N(CH2PO3)2 was synthesized and fully characterized. The prepared sample was used as catalyst in the synthesis of pyrazolo [3,4-b] pyridines as convenient medicine by condensation reaction of aldehydes, 5-(1H-Indol-3-yl)- 2H-pyrazol-3-ylamine and 3-(cyanoacetyl)indole via a CVABO. The products were obtained with high yields at 100 °C and under solvent-free conditions.

Published in Scientific Reports

ISSN: 2045-2322 (Online)
Publisher: Nature Portfolio
Country of publisher: United Kingdom
LCC subjects: Medicine; Science
Website: https://www.nature.com/srep/

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