Spike Protein Mutation-Induced Changes in the Kinetic and Thermodynamic Behavior of Its Receptor Binding Domains Explain Their Higher Propensity to Attain Open States in SARS-CoV‑2 Variants of Concern

• Jasdeep Singh,
• Shubham Vashishtha,
• Bishwajit Kundu

Affiliations

Jasdeep Singh

Department of Chemistry and Biochemistry, University of Denver, Denver, Colorado, United States

Shubham Vashishtha

Kusuma School of Biological Sciences, Indian Institute of Technology-Delhi, New Delhi, India

Bishwajit Kundu

Kusuma School of Biological Sciences, Indian Institute of Technology-Delhi, New Delhi, India