Nature Communications (Dec 2016)
PET imaging-guided chemogenetic silencing reveals a critical role of primate rostromedial caudate in reward evaluation
- Yuji Nagai,
- Erika Kikuchi,
- Walter Lerchner,
- Ken-ichi Inoue,
- Bin Ji,
- Mark A. G. Eldridge,
- Hiroyuki Kaneko,
- Yasuyuki Kimura,
- Arata Oh-Nishi,
- Yukiko Hori,
- Yoko Kato,
- Toshiyuki Hirabayashi,
- Atsushi Fujimoto,
- Katsushi Kumata,
- Ming-Rong Zhang,
- Ichio Aoki,
- Tetsuya Suhara,
- Makoto Higuchi,
- Masahiko Takada,
- Barry J. Richmond,
- Takafumi Minamimoto
Affiliations
- Yuji Nagai
- Department of Functional Brain Imaging, National Institute of Radiological Sciences, National Institutes for Quantum and Radiological Science and Technology
- Erika Kikuchi
- Department of Functional Brain Imaging, National Institute of Radiological Sciences, National Institutes for Quantum and Radiological Science and Technology
- Walter Lerchner
- Laboratory of Neuropsychology, National Institute of Mental Health, National Institutes of Health
- Ken-ichi Inoue
- Systems Neuroscience Section, Primate Research Institute, Kyoto University
- Bin Ji
- Department of Functional Brain Imaging, National Institute of Radiological Sciences, National Institutes for Quantum and Radiological Science and Technology
- Mark A. G. Eldridge
- Laboratory of Neuropsychology, National Institute of Mental Health, National Institutes of Health
- Hiroyuki Kaneko
- Department of Functional Brain Imaging, National Institute of Radiological Sciences, National Institutes for Quantum and Radiological Science and Technology
- Yasuyuki Kimura
- Department of Functional Brain Imaging, National Institute of Radiological Sciences, National Institutes for Quantum and Radiological Science and Technology
- Arata Oh-Nishi
- Department of Functional Brain Imaging, National Institute of Radiological Sciences, National Institutes for Quantum and Radiological Science and Technology
- Yukiko Hori
- Department of Functional Brain Imaging, National Institute of Radiological Sciences, National Institutes for Quantum and Radiological Science and Technology
- Yoko Kato
- Department of Functional Brain Imaging, National Institute of Radiological Sciences, National Institutes for Quantum and Radiological Science and Technology
- Toshiyuki Hirabayashi
- Department of Functional Brain Imaging, National Institute of Radiological Sciences, National Institutes for Quantum and Radiological Science and Technology
- Atsushi Fujimoto
- Department of Functional Brain Imaging, National Institute of Radiological Sciences, National Institutes for Quantum and Radiological Science and Technology
- Katsushi Kumata
- Department of Radiopharmaceuticals Development, National Institute of Radiological Sciences, National Institutes for Quantum and Radiological Science and Technology
- Ming-Rong Zhang
- Department of Radiopharmaceuticals Development, National Institute of Radiological Sciences, National Institutes for Quantum and Radiological Science and Technology
- Ichio Aoki
- Department of Molecular Imaging and Theranostics, National Institute of Radiological Sciences, National Institutes for Quantum and Radiological Science and Technology
- Tetsuya Suhara
- Department of Functional Brain Imaging, National Institute of Radiological Sciences, National Institutes for Quantum and Radiological Science and Technology
- Makoto Higuchi
- Department of Functional Brain Imaging, National Institute of Radiological Sciences, National Institutes for Quantum and Radiological Science and Technology
- Masahiko Takada
- Systems Neuroscience Section, Primate Research Institute, Kyoto University
- Barry J. Richmond
- Laboratory of Neuropsychology, National Institute of Mental Health, National Institutes of Health
- Takafumi Minamimoto
- Department of Functional Brain Imaging, National Institute of Radiological Sciences, National Institutes for Quantum and Radiological Science and Technology
- DOI
- https://doi.org/10.1038/ncomms13605
- Journal volume & issue
-
Vol. 7,
no. 1
pp. 1 – 8
Abstract
Processing the value of reward is thought to involve the rostromedial caudate (rmCD), but a causal demonstration is lacking in primates. Here the authors use chemogenetics and PET imaging to show that inactivation of rmCD leads to impairments in reward value judgments.
