Nature Communications (Oct 2018)
Indoleacetate decarboxylase is a glycyl radical enzyme catalysing the formation of malodorant skatole
- Dazhi Liu,
- Yifeng Wei,
- Xuyang Liu,
- Yan Zhou,
- Li Jiang,
- Jinyu Yin,
- Feifei Wang,
- Yiling Hu,
- Ankanahalli N. Nanjaraj Urs,
- Yanhong Liu,
- Ee Lui Ang,
- Suwen Zhao,
- Huimin Zhao,
- Yan Zhang
Affiliations
- Dazhi Liu
- Tianjin Key Laboratory for Modern Drug Delivery & High-Efficiency, Collaborative Innovation Center of Chemical Science and Engineering, School of Pharmaceutical Science and Technology, Tianjin University
- Yifeng Wei
- Metabolic Engineering Research Laboratory, Institute of Chemical and Engineering Sciences, Agency for Science, Technology and Research (A*STAR)
- Xuyang Liu
- iHuman Institute, ShanghaiTech University
- Yan Zhou
- Tianjin Key Laboratory for Modern Drug Delivery & High-Efficiency, Collaborative Innovation Center of Chemical Science and Engineering, School of Pharmaceutical Science and Technology, Tianjin University
- Li Jiang
- Tianjin Key Laboratory for Modern Drug Delivery & High-Efficiency, Collaborative Innovation Center of Chemical Science and Engineering, School of Pharmaceutical Science and Technology, Tianjin University
- Jinyu Yin
- Tianjin Key Laboratory for Modern Drug Delivery & High-Efficiency, Collaborative Innovation Center of Chemical Science and Engineering, School of Pharmaceutical Science and Technology, Tianjin University
- Feifei Wang
- Tianjin Key Laboratory for Modern Drug Delivery & High-Efficiency, Collaborative Innovation Center of Chemical Science and Engineering, School of Pharmaceutical Science and Technology, Tianjin University
- Yiling Hu
- Tianjin Key Laboratory for Modern Drug Delivery & High-Efficiency, Collaborative Innovation Center of Chemical Science and Engineering, School of Pharmaceutical Science and Technology, Tianjin University
- Ankanahalli N. Nanjaraj Urs
- Tianjin Key Laboratory for Modern Drug Delivery & High-Efficiency, Collaborative Innovation Center of Chemical Science and Engineering, School of Pharmaceutical Science and Technology, Tianjin University
- Yanhong Liu
- Technical Institute of Physics and Chemistry, Chinese Academy of Sciences
- Ee Lui Ang
- Metabolic Engineering Research Laboratory, Institute of Chemical and Engineering Sciences, Agency for Science, Technology and Research (A*STAR)
- Suwen Zhao
- iHuman Institute, ShanghaiTech University
- Huimin Zhao
- Metabolic Engineering Research Laboratory, Institute of Chemical and Engineering Sciences, Agency for Science, Technology and Research (A*STAR)
- Yan Zhang
- Tianjin Key Laboratory for Modern Drug Delivery & High-Efficiency, Collaborative Innovation Center of Chemical Science and Engineering, School of Pharmaceutical Science and Technology, Tianjin University
- DOI
- https://doi.org/10.1038/s41467-018-06627-x
- Journal volume & issue
-
Vol. 9,
no. 1
pp. 1 – 8
Abstract
Skatole is a bacterial metabolite responsible for boar taint and the objectionable smell of manure. Here, the authors elucidate the final step of skatole biosynthesis, describing the discovery and biochemical characterization of the enzyme catalysing the conversion of indoleacetate into skatole.
